CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005684
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Homeobox protein MSX-1 
Protein Synonyms/Alias
 Homeobox protein Hox-7; Msh homeobox 1-like protein 
Gene Name
 MSX1 
Gene Synonyms/Alias
 HOX7 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
9TSLPLGVKVEDSAFGsumoylation[1]
127LPEDALVKAESPEKPsumoylation[1]
231LQEAELEKLKMAAKPubiquitination[2]
237EKLKMAAKPMLPPAAubiquitination[2]
Reference
 [1] Modification of Msx1 by SUMO-1.
 Gupta V, Bei M.
 Biochem Biophys Res Commun. 2006 Jun 23;345(1):74-7. [PMID: 16678795]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity. 
Sequence Annotation
 DNA_BIND 166 225 Homeobox.
 CROSSLNK 9 9 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 127 127 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Complete proteome; Developmental protein; Disease mutation; DNA-binding; Ectodermal dysplasia; Homeobox; Isopeptide bond; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 297 AA 
Protein Sequence
MTSLPLGVKV EDSAFGKPAG GGAGQAPSAA AATAAAMGAD EEGAKPKVSP SLLPFSVEAL 60
MADHRKPGAK ESALAPSEGV QAAGGSAQPL GVPPGSLGAP DAPSSPRPLG HFSVGGLLKL 120
PEDALVKAES PEKPERTPWM QSPRFSPPPA RRLSPPACTL RKHKTNRKPR TPFTTAQLLA 180
LERKFRQKQY LSIAERAEFS SSLSLTETQV KIWFQNRRAK AKRLQEAELE KLKMAAKPML 240
PPAAFGLSFP LGGPAAVAAA AGASLYGASG PFQRAALPVA PVGLYTAHVG YSMYHLT 297 
Gene Ontology
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0000982; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0009952; P:anterior/posterior pattern specification; IEA:Compara.
 GO:0030262; P:apoptotic nuclear changes; IDA:BHF-UCL.
 GO:0061312; P:BMP signaling pathway involved in heart development; IEA:Compara.
 GO:0060349; P:bone morphogenesis; IEA:Compara.
 GO:0060536; P:cartilage morphogenesis; IEA:Compara.
 GO:0000902; P:cell morphogenesis; IDA:BHF-UCL.
 GO:0035115; P:embryonic forelimb morphogenesis; IEA:Compara.
 GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Compara.
 GO:0035880; P:embryonic nail plate morphogenesis; IMP:BHF-UCL.
 GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Compara.
 GO:0060325; P:face morphogenesis; IMP:BHF-UCL.
 GO:0030900; P:forebrain development; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0061180; P:mammary gland epithelium development; IEA:Compara.
 GO:0010463; P:mesenchymal cell proliferation; IEA:Compara.
 GO:0030901; P:midbrain development; IEA:Compara.
 GO:0042474; P:middle ear morphogenesis; IEA:Compara.
 GO:0007517; P:muscle organ development; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0030308; P:negative regulation of cell growth; IDA:BHF-UCL.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0051154; P:negative regulation of striated muscle cell differentiation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:2000678; P:negative regulation of transcription regulatory region DNA binding; IEA:Compara.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IMP:BHF-UCL.
 GO:0060021; P:palate development; IEA:Compara.
 GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Compara.
 GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; IC:BHF-UCL.
 GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IDA:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0034504; P:protein localization to nucleus; IDA:BHF-UCL.
 GO:0050821; P:protein stabilization; IDA:BHF-UCL.
 GO:0042481; P:regulation of odontogenesis; IEA:Compara.
 GO:0023019; P:signal transduction involved in regulation of gene expression; IEA:Compara. 
Interpro
 IPR017970; Homeobox_CS.
 IPR020479; Homeobox_metazoa.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like. 
Pfam
 PF00046; Homeobox 
SMART
 SM00389; HOX 
PROSITE
 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 
PRINTS
 PR00024; HOMEOBOX.