Tag | Content |
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CPLM ID | CPLM-017181 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein lifeguard 2 |
Protein Synonyms/Alias | Fas apoptotic inhibitory molecule 2; Neural membrane protein 35 |
Gene Name | Faim2 |
Gene Synonyms/Alias | Kiaa0950; Lfg; Lfg2; Nmp35 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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5 | ***MTQGKLSVANKA | ubiquitination | [1] | 11 | GKLSVANKAPGTEGQ | ubiquitination | [1] | 26 | QHQANGEKKDAPAVP | ubiquitination | [1] | 27 | HQANGEKKDAPAVPS | ubiquitination | [1] | 49 | ATSGEGLKAGTFPQG | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. |
Sequence Annotation | MOD_RES 39 39 Phosphotyrosine. CARBOHYD 192 192 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Apoptosis; Cell junction; Cell membrane; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 317 AA |
Protein Sequence | MTQGKLSVAN KAPGTEGQQH QANGEKKDAP AVPSAPPSYE EATSGEGLKA GTFPQGPTAV 60 PLHPSWAYVD PRHHEHFTTF SWDDQKVRRL FIRKVYTILL VQLLVTLAVV ALFTFCDVVK 120 DYVQANPGWY WASYAVFFAT YLTLACCSGP RRHFPWNLIL LTIFTLSMAY LTGMLSSYYN 180 TTSVLLCLVI TALVCLSVTI FSFQTKFDFT SCQGVLFVLL MTLFFSGLLL AVLLPFQYVP 240 WLHAVYAVLG AGVFTLFLAF DTQLLMGNRR HSLSPEEYIF GALNIYLDII YIFTFFLQLF 300 GTNRE 305 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0045121; C:membrane raft; IDA:UniProtKB. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0021681; P:cerebellar granular layer development; IMP:UniProtKB. GO:0021702; P:cerebellar Purkinje cell differentiation; IMP:UniProtKB. GO:0043523; P:regulation of neuron apoptotic process; IMP:UniProtKB. |
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