CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017181
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein lifeguard 2 
Protein Synonyms/Alias
 Fas apoptotic inhibitory molecule 2; Neural membrane protein 35 
Gene Name
 Faim2 
Gene Synonyms/Alias
 Kiaa0950; Lfg; Lfg2; Nmp35 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
5***MTQGKLSVANKAubiquitination[1]
11GKLSVANKAPGTEGQubiquitination[1]
26QHQANGEKKDAPAVPubiquitination[1]
27HQANGEKKDAPAVPSubiquitination[1]
49ATSGEGLKAGTFPQGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. 
Sequence Annotation
 MOD_RES 39 39 Phosphotyrosine.
 CARBOHYD 192 192 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Apoptosis; Cell junction; Cell membrane; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 317 AA 
Protein Sequence
MTQGKLSVAN KAPGTEGQQH QANGEKKDAP AVPSAPPSYE EATSGEGLKA GTFPQGPTAV 60
PLHPSWAYVD PRHHEHFTTF SWDDQKVRRL FIRKVYTILL VQLLVTLAVV ALFTFCDVVK 120
DYVQANPGWY WASYAVFFAT YLTLACCSGP RRHFPWNLIL LTIFTLSMAY LTGMLSSYYN 180
TTSVLLCLVI TALVCLSVTI FSFQTKFDFT SCQGVLFVLL MTLFFSGLLL AVLLPFQYVP 240
WLHAVYAVLG AGVFTLFLAF DTQLLMGNRR HSLSPEEYIF GALNIYLDII YIFTFFLQLF 300
GTNRE 305 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045121; C:membrane raft; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0021681; P:cerebellar granular layer development; IMP:UniProtKB.
 GO:0021702; P:cerebellar Purkinje cell differentiation; IMP:UniProtKB.
 GO:0043523; P:regulation of neuron apoptotic process; IMP:UniProtKB. 
Interpro
 IPR006214; Bax_inhibitor_1-related. 
Pfam
 PF01027; Bax1-I 
SMART
  
PROSITE
  
PRINTS