CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038641
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 IQ motif and SEC7 domain-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 Iqsec2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
409NPAYFEGKPASLDEGubiquitination[1]
913MKLDDFIKNLRGVDNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1488 AA 
Protein Sequence
MEAGSGPPGG PGSESPNRAV EYLLELNNII ESQQQLLETQ RRRIEELEGQ LDQLTQENRD 60
LREESQLHRG ELHRDPLGAR DSPGRESQYQ NLRETQFHHR ELRESQFHQA SRDVGYPNRD 120
GAYQNREAIY RDKEREASYQ LQDTTGYTAR ERDVAQCHLH HENPALGRER GGREAGPAHP 180
GREKEAGYSA AVGVGQRPPR ERGQLSRGAS RSSSPGAGGG HSTSTSTSPA TTLQRKSDGE 240
NSRTVSVEGD APGSDLSTAV DSPGSQPPYR LSQLPPTSSH MGGPPAGVGL PWAQRARLQP 300
ASVALRKQEE EEIKRSKALS DSYELSTDLQ DKKVEMLERK YGGSFLSRRA ARTIQTAFRQ 360
YRMNKNFERL RSSASESRMS RRIILSNMRM QFSFEEYEKA QNPAYFEGKP ASLDEGAMAG 420
ARSHRLERGL PYGGSCGGGI DGGGSSVTTS GEFSNDITEL EDSFSKQVKS LAESIDEALN 480
CHPSGPMSEE PGSAQLEKRE SKEQQEDSSA TSFSDLPLYL DDPVPPPSPE RLPSTEPPPQ 540
GRPEFWAPAP LPPVPPPMPP GTREDGSREE GTRRGPGCLE CRDFRLRAAH LPLLTIEPPS 600
DSSVDLSDRS DRGSVHRQLV YEADGCSPHG TLKHKGPPGR APIPHRHYPA PEGPAPAPPG 660
PLPPAPNSGT GPSGVAGGRR LGKCEAAGEN SDGGDNESLE SSSNSNETIN CSSGSSSRDS 720
LREPPATGLC KQTYQRETRH SWDSPAFNND VVQRRHYRIG LNLFNKKPEK GIQYLIERGF 780
LSDTPVGVAH FILERKGLSR QMIGEFLGNR QKQFNRDVLD CVVDEMDFSS MDLDDALRKF 840
QSHIRVQGEA QKVERLIEAF SQRYCVCNPA LVRQFRNPDT IFILAFAIIL LNTDMYSPSV 900
KAERKMKLDD FIKNLRGVDN GEDIPRDLLV GIYQRIQGRE LRTNDDHVSQ VQAVERMIVG 960
KKPVLSLPHR RLVCCCQLYE VPDPNRPQRL GLHQREVFLF NDLLVVTKIF QKKKILVTYS 1020
FRQSFPLVEM HMQLFQNSYY QFGIKLLSAV PGGERKVLII FNAPSLQDRL RFTSDLRESI 1080
AEVQEMEKYR VESELEKQKG MMRPNASQPG GAKDSVNGTL ARSSLEDTYG AGDGLKRGAL 1140
SSSLRDLSDA GKRGRRNSVG SLDSTIEGSV ISSPRPHQRM PPPPPPPPPE EYKSQRPVSN 1200
SSSFLGSLFG SKRGKGPFQM PPPPTGQASA SSSSASSTHH HHHHHHHGHS HGGLGVLPDG 1260
QSKLQALHAQ YCQGPGPAPP PYLPPQQPPL PPPPQQPPPL PQLGSIPPPP ASAPPVGPHR 1320
HFHAHGPVPG PQHYTLGRPG RAPRRGAGGH PQFAPHGRHP LHQPTSPLPL YSPAPQHPPA 1380
HKQGPKHFIF SHHPQMMPAA GAAGGPGSRP PGGSYSHPHH PQSPLSPHSP IPPHPSYPPL 1440
PPPSPHTPHS PLPPTSPHGP LHASGPPGTA NPPSANPKAK PSRISTVV 1488 
Gene Ontology
 GO:0030054; C:cell junction; IBA:RefGenome.
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0005086; F:ARF guanyl-nucleotide exchange factor activity; IBA:RefGenome.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0030036; P:actin cytoskeleton organization; IBA:RefGenome.
 GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR000904; Sec7.
 IPR023394; SEC7_alpha_orthog. 
Pfam
 PF01369; Sec7 
SMART
 SM00233; PH
 SM00222; Sec7 
PROSITE
 PS50096; IQ
 PS50190; SEC7 
PRINTS