UniProt Accession

 TEBP_MOUSE; Q9R0Q7; Q542V4; Q9D7V0; Q9WV83 

Genbank Protein ID

 AY281130; AB024935; AF153479; AK008805; AK075932; AK075987; AK077538; AK168073; AK168210; AK168721; BC003708; BC085264 

Genbank Nucleotide ID

 AAP34198.1; BAA84684.1; AAD39543.1; BAB25906.1; BAC36062.1; BAC36099.1; BAC36854.1; BAE40047.1; BAE40169.1; BAE40563.1; AAH03708.1; AAH85264.1 

Protein Name

 Prostaglandin E synthase 3 

Protein Synonyms/Alias

 Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Sid 3177; Telomerase-binding protein p23 

Gene Name

 Ptges3 

Gene Synonyms/Alias

 Sid3177; Tebp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
95	RLTKERAKLNWLSVD	acetylation	[1]
95	RLTKERAKLNWLSVD	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (By similarity). 

Sequence Annotation

 DOMAIN 1 90 CS.
 MOD_RES 33 33 N6-acetyllysine (By similarity).
 MOD_RES 113 113 Phosphoserine.
 MOD_RES 118 118 Phosphoserine (By similarity).
 MOD_RES 148 148 Phosphoserine.
 MOD_RES 151 151 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Fatty acid biosynthesis; Fatty acid metabolism; Isomerase; Lipid biosynthesis; Lipid metabolism; Phosphoprotein; Prostaglandin biosynthesis; Prostaglandin metabolism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 160 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005697; C:telomerase holoenzyme complex; IEA:Compara.
 GO:0050220; F:prostaglandin-E synthase activity; ISS:UniProtKB.
 GO:0003720; F:telomerase activity; IEA:Compara.
 GO:0051082; F:unfolded protein binding; ISS:UniProtKB.
 GO:0070389; P:chaperone cofactor-dependent protein refolding; IEA:Compara.
 GO:0001516; P:prostaglandin biosynthetic process; ISS:UniProtKB. 

Interpro

 IPR007052; CS-like_domain.
 IPR017447; CS_domain.
 IPR008978; HSP20-like_chaperone. 

Pfam

 PF04969; CS 

SMART

  

PROSITE

 PS51203; CS 

PRINTS