CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041079
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Histone-lysine N-methyltransferase MLL4 
Protein Synonyms/Alias
  
Gene Name
 Kmt2b 
Gene Synonyms/Alias
 Wbp7 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1698HTDLLDGKEIVTPDGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Methyltransferase; Nucleus; Reference proteome; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2721 AA 
Protein Sequence
MAAAAGGGSC PGPGSARGRF PGRPRGSGGG GGRGGRGNGA ERVRVALRRG GGAAGPGGAE 60
PGEDTALLRL LGLRRGLRRL RRLWAGARVQ RGRGRGRGRG WGPNRGCMPE EESSDGESEE 120
EEFQGFHSDE DVAPSSLRSA LRSQRGRAPR GRGRKHKTTP LPPRLADVTP VPPKAPTRKR 180
GEEGTERMVQ ALTELLRRSQ APQPPRSRAR AREPSTPRRS RGRPPGRPAG PCRKKQQAVV 240
LAEAAVTIPK PEPPPPVVPV KNKAGSWKCK EGPGPGPGTP KRGGQPGRGG RGGRGRGRGG 300
LPLMIKFVSK AKKVKMGQLS QELESGQGHG QRGESWQDAP QRKDGDEPER GSCRKKQEQK 360
LEEEEEEEEK EGEEKEEKDD NEDNNKQEEE EETERAVAEE EAMLAKEKEE AKLPSPPLTP 420
PVPSPPPPLP PPSTSPPPPA SPLPPPVSPP PPLSPPPYPA PEKQEESPPL VPATCSRKRG 480
RPPLTPSQRA EREAARSGPE GTLSPTPNPS TTTGSPLEDS PTVVPKSTTF LKNIRQFIMP 540
VVSARSSRVI KTPRRFMDED PPKPPKVEAS IVRPPVATSP PAPQEPVPVS SPPRVPTPPS 600
TPVPLPEKRR SILREPTFRW TSLTRELPPP PPAPPPAPSP PPAPATPSRR PLLLRAPQFT 660
PSEAHLKIYE SVLTPPPLGA LETPEPELPP ADDSPAEPEP RAVGRTNHLS LPRFVPVVTS 720
PVKVEVPPHG APALSEGQQL QLQQPPQALQ TQLLPQALPP QQPQAQPPPS PQHTPPLEKA 780
RVASLGSLPL SGVEEKMFSL LKRAKVQLFK IDQQQQQKVA ASMPLSPAVQ TEEAVGTVKQ 840
TPDRGCVRSE DESMEAKRDR ASGPESPLQG PRIKHVCRHA AVALGQARAM VPEDVPRLSA 900
LPLRDRQDLA TEDTSSASET ESVPSRSQRE KVESAGPGGD SEPTGSTGAL AHTPRRSLPS 960
HHGKKMRMAR CGHCRGCLRV QDCGSCVNCL DKPKFGGPNT KKQCCVYRKC DKIEARKMER 1020
LAKKGRTIVK TLLPWDSDES PEASPGPPGP RRGAGAGGSR EEVGATPGPE EQDSLLLQRK 1080
SARRCVKQRP SYDVFEDSDD SEPGGPPAPR RRTPREHELP VLEPEEQSRP RKPTLQPVLQ 1140
LKARRRLDKD ALAPGPFASF PNGWTGKQKS PDGVHRVRVD FKEDCDLENV WLMGGLSVLT 1200
SVPGGPPMVC LLCASKGLHE LVFCQVCCDP FHPFCLEEAE RPSPQHRDTW CCRRCKFCHV 1260
CGRKGRGSKH LLECERCRHA YHPACLGPSY PTRATRRRRH WICSACVRCK SCGATPGKNW 1320
DVEWSGDYSL CPRCTELYEK GNYCPICTRC YEDNDYESKM MQCAQCDHWV HAKCEGLSDE 1380
DYEILSGLPD SVLYTCGPCA GATQPRWREA LSGALQGGLR QVLQGLLSSK VAGPLLLCTQ 1440
CGQDGKQLHP GPCDLQAVGK RFEEGLYKSV HSFMEDVVAI LMRHSEEGET PERRAGSQMK 1500
GLLLKLLESA FCWFDAHDPK YWRRSTRLPN GVLPNAVLPP SLDHVYAQWR QQESETPESG 1560
QPPGDPSAAF QSKDPAAFSH LDDPRQCALC LKYGDADSKE AGRLLYIGQN EWTHVNCAIW 1620
SAEVFEENDG SLKNVHAAVA RGRQMRCELC LKPGATVGCC LSSCLSNFHF MCARASYCIF 1680
QDDKKVFCQK HTDLLDGKEI VTPDGFDVLR RVYVDFEGIN FKRKFLTGLE PDVINVLIGS 1740
IRINSLGTLS DLSDCEGRLF PIGYQCSRLY WSTVDARRRC WYRCRILEYR PWGPREEPVH 1800
LEAAEENQTI VHSPTPSSEP PNHDDLPDTD SLIPGDPVHH SPIQNLDPPL RTDSSNGPPP 1860
TPRSFSGARI KVPNYSPSRR PLGGVSFGPL PSPGSPSSLT HHIPTVGDSD FPAPPRRSRR 1920
PSPLATRPPP SRRTSSPLRT SPQLRVPLST SVTALTPTSG ELAPPDLAPS PLPPSEDLGP 1980
DFEDMEVVSG LSAADLDFAA SLLGTEPFQE EIVAAGAVGS SQGGPGDSSE EEASPTTHYV 2040
HFPVTVVSGP ALAPSSLAGA PRIEQLDGVD DGTDSEAEAV QQPRGQGTPP SGPGVGRGGV 2100
LGAAGDRAQP PEDLPSEIVD FVLKNLGGPG EGAAGPREDS LPSAPPLANG SQPPQSLSTS 2160
PADPTRTFAW LPGAPGVRVL SLGPAPEPPK PATSKIILVN KLGQVFVKMA GEGEPVAPPV 2220
KQPPLPPIIP PTAPTSWTLP PGPLLSVLPV VGVGVVRPAP PPPPPPLTLV FSSGPPSPPR 2280
QAIRVKRVST FSGRSPPVPP PNKTPRLDED GESLEDAHHV PGISGSGFSR VRMKTPTVRG 2340
VLDLNNPGEQ PEEESPGRPQ DRCPLLPLAE APSQALDGSS DLLFESQWHH YSGEASSSEE 2400
EPPSPEDKEN QVPKRVGPHL RFEISSDDGF SVEAESLEVA WRTLIEKVQE ARGHARLRHL 2460
SFSGMSGARL LGIHHDAVIF LAEQLPGAQR CQHYKFRYHQ QGEGQEEPPL NPHGAARAEV 2520
YLRKCTFDMF NFLASQHRVL PEGATCDEEE DEVQLRSTRR ATSLELPMAM RFRHLKKTSK 2580
EAVGVYRSAI HGRGLFCKRN IDAGEMVIEY SGIVIRSVLT DKREKFYDGK GIGCYMFRMD 2640
DFDVVDATMH GNAARFINHS CEPNCFSRVI HVEGQKHIVI FALRRILRGE ELTYDYKFPI 2700
EDASNKLPCN CGAKRCRRFL N 2721 
Gene Ontology
 GO:0035097; C:histone methyltransferase complex; ISO:MGI.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0042800; F:histone methyltransferase activity (H3-K4 specific); ISO:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0016458; P:gene silencing; IMP:MGI.
 GO:0080182; P:histone H3-K4 trimethylation; IMP:MGI.
 GO:0009994; P:oocyte differentiation; IMP:MGI.
 GO:0001541; P:ovarian follicle development; IMP:MGI.
 GO:0030728; P:ovulation; IMP:MGI.
 GO:0051569; P:regulation of histone H3-K4 methylation; IMP:MGI. 
Interpro
 IPR017956; AT_hook_DNA-bd_motif.
 IPR003889; FYrich_C.
 IPR003888; FYrich_N.
 IPR015722; Histone-lysine_MeTfrase.
 IPR003616; Post-SET_dom.
 IPR001214; SET_dom.
 IPR002857; Znf_CXXC.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF05965; FYRC
 PF05964; FYRN
 PF00628; PHD
 PF00856; SET
 PF02008; zf-CXXC 
SMART
 SM00384; AT_hook
 SM00542; FYRC
 SM00541; FYRN
 SM00249; PHD
 SM00508; PostSET
 SM00317; SET 
PROSITE
 PS51543; FYRC
 PS51542; FYRN
 PS50868; POST_SET
 PS50280; SET
 PS51058; ZF_CXXC
 PS50016; ZF_PHD_2 
PRINTS