CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004456
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial 
Protein Synonyms/Alias
 Pyruvate dehydrogenase complex component E1 alpha; PDHE1-A 
Gene Name
 PDA1 
Gene Synonyms/Alias
 YER178W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
103MACDALYKAKKIRGFacetylation[1]
264SAMTEYFKRGQYIPGacetylation[1]
287LAVYQASKFAKDWCLacetylation[1]
333EIQHMRSKNDPIAGLacetylation[1]
360AEVKAYDKSARKYVDacetylation[1]
364AYDKSARKYVDEQVEacetylation[1]
412PEDTWDFKKQGFASRacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). 
Sequence Annotation
 MOD_RES 313 313 Phosphoserine.  
Keyword
 Complete proteome; Direct protein sequencing; Glycolysis; Mitochondrion; Oxidoreductase; Phosphoprotein; Pyruvate; Reference proteome; Thiamine pyrophosphate; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 420 AA 
Protein Sequence
MLAASFKRQP SQLVRGLGAV LRTPTRIGHV RTMATLKTTD KKAPEDIEGS DTVQIELPES 60
SFESYMLEPP DLSYETSKAT LLQMYKDMVI IRRMEMACDA LYKAKKIRGF CHLSVGQEAI 120
AVGIENAITK LDSIITSYRC HGFTFMRGAS VKAVLAELMG RRAGVSYGKG GSMHLYAPGF 180
YGGNGIVGAQ VPLGAGLAFA HQYKNEDACS FTLYGDGASN QGQVFESFNM AKLWNLPVVF 240
CCENNKYGMG TAASRSSAMT EYFKRGQYIP GLKVNGMDIL AVYQASKFAK DWCLSGKGPL 300
VLEYETYRYG GHSMSDPGTT YRTRDEIQHM RSKNDPIAGL KMHLIDLGIA TEAEVKAYDK 360
SARKYVDEQV ELADAAPPPE AKLSILFEDV YVKGTETPTL RGRIPEDTWD FKKQGFASRD 420 
Gene Ontology
 GO:0042645; C:mitochondrial nucleoid; IDA:SGD.
 GO:0005967; C:mitochondrial pyruvate dehydrogenase complex; IDA:SGD.
 GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IMP:SGD.
 GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IDA:SGD.
 GO:0006096; P:glycolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001017; DH_E1.
 IPR017597; Pyrv_DH_E1_asu_subgrp-y. 
Pfam
 PF00676; E1_dh 
SMART
  
PROSITE
  
PRINTS