UniProt Accession

 C42S2_HUMAN; Q9NRR3; B2R622; Q4KMT9 

Genbank Protein ID

 AF189692; AK312406; CH471062; BC096703; BC096738; BC098349 

Genbank Nucleotide ID

 AAF87598.1; BAG35319.1; EAW62373.1; AAH96703.1; AAH96738.1; AAH98349.1 

Protein Name

 CDC42 small effector protein 2 

Protein Synonyms/Alias

 Small effector of CDC42 protein 2 

Gene Name

 CDC42SE2 

Gene Synonyms/Alias

 SPEC2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
82	QMQLVDTKAG*****	ubiquitination	[1, 2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. 

Sequence Annotation

 DOMAIN 29 42 CRIB.
 LIPID 10 10 S-palmitoyl cysteine.
 LIPID 11 11 S-palmitoyl cysteine.  

Keyword

 Cell membrane; Cell projection; Cell shape; Complete proteome; Cytoplasm; Cytoskeleton; Lipoprotein; Membrane; Palmitate; Phagocytosis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 84 AA 

Protein Sequence

Gene Ontology

 GO:0042995; C:cell projection; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0001891; C:phagocytic cup; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0005198; F:structural molecule activity; IDA:UniProtKB.
 GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
 GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
 GO:0009966; P:regulation of signal transduction; IDA:UniProtKB. 

Interpro

 IPR000095; PAK_box_Rho-bd. 

Pfam

 PF00786; PBD 

SMART

  

PROSITE

 PS50108; CRIB 

PRINTS