CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022146
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Midasin 
Protein Synonyms/Alias
 MIDAS-containing protein 
Gene Name
 MDN1 
Gene Synonyms/Alias
 KIAA0301 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
22LIAAKNEKSRSELGRubiquitination[1]
33ELGRFLAKQVWTPQDubiquitination[1, 2, 3]
81ERNAEAIKAGGQINHubiquitination[1, 2, 3]
100RLCVSMSKLIGNHPDubiquitination[1]
117PFALRYFKDTSPVFQubiquitination[1, 2, 3, 4, 5]
208HKLSFLKKIFNSDELubiquitination[1]
247PEVSLWRKQKELQYLubiquitination[1]
249VSLWRKQKELQYLQGubiquitination[1, 2]
350AAVTGRTKPPQLLKVubiquitination[1, 2]
356TKPPQLLKVQLGDQTubiquitination[1, 2]
366LGDQTDSKMLLGMYRubiquitination[1, 2, 3]
433PGRGDCLKVAPGFQFubiquitination[1, 6, 7]
466SHATLLDKYWTKIHLubiquitination[1]
478IHLDNLDKRELNEVLubiquitination[1, 2, 7]
592SEHTSKLKMAEVIGSubiquitination[1, 2]
600MAEVIGSKLNISRKKubiquitination[1, 2, 3]
636GRVRLLRKQSEAVHLubiquitination[1]
683VGETGTGKTSTIQYLubiquitination[1]
717ADLLGGYKPVDHKLIubiquitination[1, 2]
722GYKPVDHKLIWLPLRubiquitination[1]
742LFAQTFSKKQNFTFLubiquitination[1]
743FAQTFSKKQNFTFLGubiquitination[1]
778VHKSAVNKDGKDSETubiquitination[1, 2]
781SAVNKDGKDSETGLLubiquitination[1, 2]
790SETGLLIKEKWEAFGubiquitination[2]
792TGLLIKEKWEAFGLRubiquitination[1]
891NPATDVGKRNLPPGIubiquitination[1]
931LKGLSVNKNTVQGIIubiquitination[1]
1008ASHPIVQKLICQHIVubiquitination[1]
1020HIVPGNVKSLLKQPIubiquitination[1]
1024GNVKSLLKQPIPEPKubiquitination[1, 2, 3]
1031KQPIPEPKGGRLIQVubiquitination[1]
1184TETQEVVKAHPRFMLubiquitination[1, 2, 3]
1234ELETILHKRCSLPPSubiquitination[1, 2]
1248SYCSKLVKVMLDLQSubiquitination[2]
1266SSSVFAGKQGFITLRubiquitination[1, 2]
1312LLAGRVRKQEEIDVIubiquitination[1]
1344FSKENVLKLLGKLSTubiquitination[1]
1435GLRPVRQKPNDKEEIubiquitination[1]
1439VRQKPNDKEEIDTSRubiquitination[2]
1489NSVLEVEKSLVLAEKubiquitination[1, 2, 6]
1502EKGSPEDKDSEIELLubiquitination[1, 2]
1513IELLTAGKKFRILATubiquitination[2, 3]
1514ELLTAGKKFRILATMubiquitination[1]
1529NPGGDFGKKELSPALubiquitination[2]
1530PGGDFGKKELSPALRubiquitination[1]
1597THQEFGRKCVVSIRDubiquitination[1]
1683VRLTEYQKNELKIYDacetylation[8]
1683VRLTEYQKNELKIYDubiquitination[2]
1687EYQKNELKIYDRMKAubiquitination[1, 2]
1695IYDRMKAKEFTGIDNubiquitination[1, 6]
1746LLRATKLKKPILLEGubiquitination[1]
1747LRATKLKKPILLEGSubiquitination[1]
1768SLVGALAKASGNTLVubiquitination[1, 2]
1799DLPVEGGKGGEFAWRubiquitination[2]
1863QVQHEKTKIFGCQNPubiquitination[1]
1940VEKKWGQKGGPWEFNubiquitination[1, 2, 4, 5]
1989RTEEDKKKVIAVFKDubiquitination[1]
1995KKVIAVFKDVFGSNSubiquitination[1]
2120PWRRLLEKVEGTVRAubiquitination[2]
2198YCKAEFAKLVEEFRSubiquitination[2]
2406QHSPANRKLVQALLEubiquitination[1, 7]
2414LVQALLEKHVSSLRAubiquitination[1, 2]
2471CLNRMSMKTSSWTRSubiquitination[1]
2488FTLQDLEKIMQSPSPubiquitination[2]
2656NLVSVGSKKLRESVLubiquitination[1, 2]
2657LVSVGSKKLRESVLRubiquitination[1]
2825SQLKVLNKVLAIREQubiquitination[1]
2858VASQWTLKKSLLQAWubiquitination[2]
2896QCLELKAKGLSLGFLubiquitination[1, 2, 7]
2905LSLGFLEKKHDEASSubiquitination[2, 4, 5]
2906SLGFLEKKHDEASSLubiquitination[1, 7]
3056SVLDSTLKGPGNLNRubiquitination[1, 2, 4, 5, 7]
3211FVGEGESKRSLPEPAubiquitination[1]
3246ARFDPAVKREYKLNYubiquitination[1, 2]
3250PAVKREYKLNYVKEEubiquitination[1]
3255EYKLNYVKEELHQLQubiquitination[1, 7]
3312NLTCHLLKKQAFRPQacetylation[7]
3312NLTCHLLKKQAFRPQubiquitination[1]
3313LTCHLLKKQAFRPQLubiquitination[1]
3370QVAQSLLKEEASWQQubiquitination[1, 2, 7]
3473EVLRGLGKLILKRSGubiquitination[1, 7]
3482ILKRSGGKELEGKGQacetylation[7]
3513LRSHVLCKGELDQRAubiquitination[1, 7]
3545QERIAQEKAEQESGLubiquitination[1, 2, 7]
3950KEFVKISKWNDVSFWubiquitination[1]
3960DVSFWSIKQSVEKTHubiquitination[1]
3972KTHRTLFKFMKKFEAubiquitination[1]
3976TLFKFMKKFEAVLSEubiquitination[1]
4066KLRKRMRKMCLTFMKubiquitination[1]
4132RALSDLFKHLAKIGLubiquitination[1, 4, 5]
4143KIGLSYRKGLAWARSubiquitination[1]
4194SSWDGCQKYFYRSLAubiquitination[1]
4215AALATPAKEMGMGNVubiquitination[1, 2, 4, 5]
4375PSGCRMRKQDHLWQQubiquitination[1]
4392TRLTEMLKTIKTVKAubiquitination[1]
4705QVEDTFQKGQEKDKEacetylation[9]
4736MSEDFDGKMHDGELEubiquitination[6]
5168QTYDVASKEQQQSAKacetylation[9]
5253HKETENEKPERSRESubiquitination[2]
5342LEPTQAAKLKGDYRTubiquitination[1, 2]
5344PTQAAKLKGDYRTGKubiquitination[1]
5357GKRLNIRKVIPYIASubiquitination[1]
5506RGLFLEGKERVLAAVubiquitination[1, 2]
5541RDSILDIKVPIFKGPubiquitination[1, 2, 3, 4, 5]
5546DIKVPIFKGPGEMPEubiquitination[1, 2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [8] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [9] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (By similarity). 
Sequence Annotation
 DOMAIN 5384 5583 VWFA.
 NP_BIND 329 336 ATP (Potential).
 NP_BIND 677 684 ATP (Potential).
 NP_BIND 1084 1091 ATP (Potential).
 NP_BIND 1390 1397 ATP (Potential).
 NP_BIND 1753 1760 ATP (Potential).
 NP_BIND 2066 2073 ATP (Potential).
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 1177 1177 Phosphothreonine.
 MOD_RES 1683 1683 N6-acetyllysine.
 MOD_RES 4538 4538 Phosphoserine.
 MOD_RES 4752 4752 Phosphoserine.
 MOD_RES 4754 4754 Phosphoserine.
 MOD_RES 4889 4889 Phosphoserine.
 MOD_RES 4898 4898 Phosphothreonine.
 MOD_RES 4937 4937 Phosphoserine.
 MOD_RES 4946 4946 Phosphoserine.
 MOD_RES 5015 5015 Phosphoserine.  
Keyword
 Acetylation; ATP-binding; Chaperone; Complete proteome; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 5596 AA 
Protein Sequence
MEHFLLEVAA APLRLIAAKN EKSRSELGRF LAKQVWTPQD RQCVLSTLAQ LLLDKDCTVL 60
VGRQLRPLLL DLLERNAEAI KAGGQINHDL HERLCVSMSK LIGNHPDVLP FALRYFKDTS 120
PVFQRLFLES SDANPVRYGR RRMKLRDLME AAFKFLQQEQ SVFRELWDWS VCVPLLRSHD 180
TLVRWYTANC LALVTCMNEE HKLSFLKKIF NSDELIHFRL RLLEEAQLQD LEKALVLANP 240
EVSLWRKQKE LQYLQGHLVS SDLSPRVTAV CGVVLPGQLP APGELGGNRS SSREQELALR 300
SYVLVESVCK SLQTLAMAVA SQNAVLLEGP IGCGKTSLVE YLAAVTGRTK PPQLLKVQLG 360
DQTDSKMLLG MYRCTDVPGE FVWQPGTLTQ AATMGHWILL EDIDYAPLDV VSVLIPLLEN 420
GELLIPGRGD CLKVAPGFQF FATRRLLSCG GNWYRPLNSH ATLLDKYWTK IHLDNLDKRE 480
LNEVLQSRYP SLLAVVDHLL DIYIQLTGEK HHSWSDSSVG CEQAPEEVSE ARRENKRPTL 540
EGRELSLRDL LNWCNRIAHS FDSSSLSASL NIFQEALDCF TAMLSEHTSK LKMAEVIGSK 600
LNISRKKAEF FCQLYKPEIV INELDLQVGR VRLLRKQSEA VHLQREKFTF AATRPSSVLI 660
EQLAVCVSKG EPVLLVGETG TGKTSTIQYL AHITGHRLRV VNMNQQSDTA DLLGGYKPVD 720
HKLIWLPLRE AFEELFAQTF SKKQNFTFLG HIQTCYRQKR WHDLLRLMQH VHKSAVNKDG 780
KDSETGLLIK EKWEAFGLRL NHAQQQMKMT ENTLLFAFVE GTLAQAVKKG EWILLDEINL 840
AAPEILECLS GLLEGSSGSL VLLDRGDTEP LVRHPDFRLF ACMNPATDVG KRNLPPGIRN 900
RFTELYVEEL ESKEDLQVLI VDYLKGLSVN KNTVQGIINF YTALRKESGT KLVDGTGHRP 960
HYSLRTLCRA LRFAASNPCG NIQRSLYEGF CLGFLTQLDR ASHPIVQKLI CQHIVPGNVK 1020
SLLKQPIPEP KGGRLIQVEG YWIAVGDKEP TIDETYILTS SVKLNLRDIV RVVSAGTYPV 1080
LIQGETSVGK TSLIQWLAAA TGNHCVRINN HEHTDIQEYI GCYTSDSSGK LVFKEGVLID 1140
AMRKGYWIIL DELNLAPTDV LEALNRLLDD NRELLVTETQ EVVKAHPRFM LFATQNPPGL 1200
YGGRKVLSRA FRNRFVELHF DELPSSELET ILHKRCSLPP SYCSKLVKVM LDLQSYRRSS 1260
SVFAGKQGFI TLRDLFRWAE RYRLAEPTEK EYDWLQHLAN DGYMLLAGRV RKQEEIDVIQ 1320
EVLEKHFKKK LCPQSLFSKE NVLKLLGKLS TQISTLECNF GHIVWTEGMR RLAMLVGRAL 1380
EFGEPVLLVG DTGCGKTTIC QVFAALANQK LYSVSCHLHM ETSDFLGGLR PVRQKPNDKE 1440
EIDTSRLFEW HDGPLVQAMK EDGFFLLDEI SLADDSVLER LNSVLEVEKS LVLAEKGSPE 1500
DKDSEIELLT AGKKFRILAT MNPGGDFGKK ELSPALRNRF TEIWCPQSTS REDLIQIISH 1560
NLRPGLCLGR IDPKGSDIPE VMLDFIDWLT HQEFGRKCVV SIRDILSWVN FMNKMGEEAA 1620
LKRPEIISTV TSFVHAACLV YIDGIGSGVT SSGFGTALLA RKECLKFLIK RLAKIVRLTE 1680
YQKNELKIYD RMKAKEFTGI DNLWGIHPFF IPRGPVLHRN NIADYALSAG TTAMNAQRLL 1740
RATKLKKPIL LEGSPGVGKT SLVGALAKAS GNTLVRINLS EQTDITDLFG ADLPVEGGKG 1800
GEFAWRDGPL LAALKAGHWV VLDELNLASQ SVLEGLNACF DHRGEIYVPE LGMSFQVQHE 1860
KTKIFGCQNP FRQGGGRKGL PRSFLNRFTQ VFVDPLTVID MEFIASTLFP AIEKNIVKKM 1920
VAFNNQIDHE VTVEKKWGQK GGPWEFNLRD LFRWCQLMLV DQSPGCYDPG QHVFLVYGER 1980
MRTEEDKKKV IAVFKDVFGS NSNPYMGTRL FRITPYDVQL GYSVLSRGSC VPHPSRHPLL 2040
LLHQSFQPLE SIMKCVQMSW MVILVGPASV GKTSLVQLLA HLTGHTLKIM AMNSAMDTTE 2100
LLGGFEQVDL IRPWRRLLEK VEGTVRALLR DSLLISADDA EVVLRAWSHF LLTYKPKCLG 2160
EGGKAITMEI VNKLEAVLLL MQRLNNKINS YCKAEFAKLV EEFRSFGVKL TQLASGHSHG 2220
TFEWVDSMLV QALKSGDWLL MDNVNFCNPS VLDRLNALLE PGGVLTISER GMIDGSTPTI 2280
TPNPNFRLFL SMDPVHGDIS RAMRNRGLEI YISGEGDAST PDNLDLKVLL HSLGLVGNSV 2340
CDILLALHTE TRSTVVGSPT SSVSTLIQTA ILIVQYLQRG LSLDRAFSEA CWEVYVCSQH 2400
SPANRKLVQA LLEKHVSSLR AHETWGDSIL GMGLWPDSVP SALFATEDSH LSTVRRDGQI 2460
LVYCLNRMSM KTSSWTRSQP FTLQDLEKIM QSPSPENLKF NAVEVNTYWI DEPDVLVMAV 2520
KLLIERATNQ DWMLRVKWLY HLAKNIPQGL ESIQIHLEAS AASLRNFYSH SLSGAVSNVF 2580
KILQPNTTDE FVIPLDPRWN MQALDMIRNL MDFDPQTDQP DQLFALLESA ANKTIIYLDR 2640
EKRVFTEANL VSVGSKKLRE SVLRMSFEFH QDPESYHTLP HEIVVNLAAF FELCDALVLL 2700
WVQSSQGMVS DASANEILGS LRWRDRFWTV ADTVKVDAPG LALLALHWHW VLKHLVHQIP 2760
RLLMNYEDKY YKEVQTVSEH IQNCLGSQTG GFAGIKKLQK FLGRPFPFKD KLVVECFSQL 2820
KVLNKVLAIR EQMSALGESG WQEDINRLQV VASQWTLKKS LLQAWGLILR ANILEDVSLD 2880
ELKNFVHAQC LELKAKGLSL GFLEKKHDEA SSLSHPDLTS VIHLTRSVQL WPAMEYLAML 2940
WRYKVTADFM AQACLRRCSK NQQPQINEEI SHLISFCLYH TPVTPQELRD LWSLLHHQKV 3000
SPEEITSLWS ELFNSMFMSF WSSTVTTNPE YWLMWNPLPG MQQREAPKSV LDSTLKGPGN 3060
LNRPIFSKCC FEVLTSSWRA SPWDVSGLPI LSSSHVTLGE WVERTQQLQD ISSMLWTNMA 3120
ISSVAEFRRT DSQLQGQVLF RHLAGLAELL PESRRQEYMQ NCEQLLLGSS QAFQHVGQTL 3180
GDMAGQEVLP KELLCQLLTS LHHFVGEGES KRSLPEPAQR GSLWVSLGLL QIQTWLPQAR 3240
FDPAVKREYK LNYVKEELHQ LQCEWKTRNL SSQLQTGRDL EDEVVVSYSH PHVRLLRQRM 3300
DRLDNLTCHL LKKQAFRPQL PAYESLVQEI HHYVTSIAKA PAVQDLLTRL LQALHIDGPR 3360
SAQVAQSLLK EEASWQQSHH QFRKRLSEEY TFYPDAVSPL QASILQLQHG MRLVASELHT 3420
SLHSSMVGAD RLGTLATALL AFPSVGPTFP TYYAHADTLC SVKSEEVLRG LGKLILKRSG 3480
GKELEGKGQK ACPTREQLLM NALLYLRSHV LCKGELDQRA LQLFRHVCQE IISEWDEQER 3540
IAQEKAEQES GLYRYRSRNS RTALSEEEEE EREFRKQFPL HEKDFADILV QPTLEENKGT 3600
SDGQEEEAGT NPALLSQNSM QAVMLIHQQL CLNFARSLWY QQTLPPHEAK HYLSLFLSCY 3660
QTGASLVTHF YPLMGVELND RLLGSQLLAC TLSHNTLFGE APSDLMVKPD GPYDFYQHPN 3720
VPEARQCQPV LQGFSEAVSH LLQDWPEHPA LEQLLVVMDR IRSFPLSSPI SKFLNGLEIL 3780
LAKAQDWEEN ASRALSLRKH LDLISQMIIR WRKLELNCWS MSLDNTMKRH TEKSTKHWFS 3840
IYQMLEKHMQ EQTEEQEDDK QMTLMLLVST LQAFIEGSSL GEFHVRLQML LVFHCHVLLM 3900
PQVEGKDSLC SVLWNLYHYY KQFFDRVQAK IVELRSPLEK ELKEFVKISK WNDVSFWSIK 3960
QSVEKTHRTL FKFMKKFEAV LSEPCRSSLV ESDKEEQPDF LPRPTDGAAS ELSSIQNLNR 4020
ALRETLLAQP AAGQATIPEW CQGAAPSGLE GELLRRLPKL RKRMRKMCLT FMKESPLPRL 4080
VEGLDQFTGE VISSVSELQS LKVEPSAEKE KQRSEAKHIL MQKQRALSDL FKHLAKIGLS 4140
YRKGLAWARS KNPQEMLHLH PLDLQSALSI VSSTQEADSR LLTEISSSWD GCQKYFYRSL 4200
ARHARLNAAL ATPAKEMGMG NVERCRGFSA HLMKMLVRQR RSLTTLSEQW IILRNLLSCV 4260
QEIHSRLMGP QAYPVAFPPQ DGVQQWTERL QHLAMQCQIL LEQLSWLLQC CPSVGPAPGH 4320
GNVQVLGQPP GPCLEGPELS KGQLCGVVLD LIPSNLSYPS PIPGSQLPSG CRMRKQDHLW 4380
QQSTTRLTEM LKTIKTVKAD VDKIRQQSCE TLFHSWKDFE VCSSALSCLS QVSVHLQGLE 4440
SLFILPGMEV EQRDSQMALV ESLEYVRGEI SKAMADFTTW KTHLLTSDSQ GGNQMLDEGF 4500
VEDFSEQMEI AIRAILCAIQ NLEERKNEKA EENTDQASPQ EDYAGFERLQ SGHLTKLLED 4560
DFWADVSTLH VQKIISAISE LLERLKSYGE DGTAAKHLFF SQSCSLLVRL VPVLSSYSDL 4620
VLFFLTMSLA THRSTAKLLS VLAQVFTELA QKGFCLPKEF MEDSAGEGAT EFHDYEGGGI 4680
GEGEGMKDVS DQIGNEEQVE DTFQKGQEKD KEDPDSKSDI KGEDNAIEMS EDFDGKMHDG 4740
ELEEQEEDDE KSDSEGGDLD KHMGDLNGEE ADKLDERLWG DDDEEEDEEE EDNKTEETGP 4800
GMDEEDSELV AKDDNLDSGN SNKDKSQQDK KEEKEEAEAD DGGQGEDKIN EQIDERDYDE 4860
NEVDPYHGNQ EKVPEPEALD LPDDLNLDSE DKNGGEDTDN EEGEEENPLE IKEKPEEAGH 4920
EAEERGETET DQNESQSPQE PEEGPSEDDK AEGEEEMDTG ADDQDGDAAQ HPEEHSEEQQ 4980
QSVEEKDKEA DEEGGENGPA DQGFQPQEEE EREDSDTEEQ VPEALERKEH ASCGQTGVEN 5040
MQNTQAMELA GAAPEKEQGK EEHGSGAADA NQAEGHESNF IAQLASQKHT RKNTQSFKRK 5100
PGQADNERSM GDHNERVHKR LRTVDTDSHA EQGPAQQPQA QVEDADAFEH IKQGSDAYDA 5160
QTYDVASKEQ QQSAKDSGKD QEEEEIEDTL MDTEEQEEFK AADVEQLKPE EIKSGTTAPL 5220
GFDEMEVEIQ TVKTEEDQDP RTDKAHKETE NEKPERSRES TIHTAHQFLM DTIFQPFLKD 5280
VNELRQELER QLEMWQPRES GNPEEEKVAA EMWQSYLILT APLSQRLCEE LRLILEPTQA 5340
AKLKGDYRTG KRLNIRKVIP YIASQFRKDK IWLRRTKPSK RQYQICLAID DSSSMVDNHT 5400
KQLAFESLAV IGNALTLLEV GQIAVCSFGE SVKLLHPFHE QFSDYSGSQI LRLCKFQQKK 5460
TKIAQFLESV ANMFAAAQQL SQNISSETAQ LLLVVSDGRG LFLEGKERVL AAVQAARNAN 5520
IFVIFVVLDN PSSRDSILDI KVPIFKGPGE MPEIRSYMEE FPFPYYIILR DVNALPETLS 5580
DALRQWFELV TASDHP 5596 
Gene Ontology
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; NAS:UniProtKB.
 GO:0051082; F:unfolded protein binding; NAS:UniProtKB.
 GO:0006461; P:protein complex assembly; NAS:UniProtKB. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR011704; ATPase_dyneun-rel_AAA.
 IPR012099; Midasin.
 IPR027417; P-loop_NTPase.
 IPR002035; VWF_A. 
Pfam
 PF07728; AAA_5 
SMART
 SM00382; AAA
 SM00327; VWA 
PROSITE
 PS50234; VWFA 
PRINTS