CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040301
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 
Protein Synonyms/Alias
  
Gene Name
 Usp34 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
2025CKTYTMDKQPLNTGEubiquitination[1]
2157FNMVTMMKEKVNTHFubiquitination[1]
2159MVTMMKEKVNTHFSFubiquitination[1]
3157FPCRENIKLIGGKSNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3602 AA 
Protein Sequence
XRSGSVSAIL SGGGGGGGRT MCENCADLVE VLNEISDIEG GDGLQLRKEH TLKIFAYINS 60
WTQRQCLCCF KEYKHLEIFN QVVCALINLV IAQVQVLRDQ LCKHCTTINI DSTWQDESNQ 120
AEEPLSIDRE CNEGNTERQK SIEKKSNSTR TCNLTEEESS KSSDPFSLWN TDEKEKLLLC 180
VAKIFQIQFP LYTAYKHNTH PTIEDISTQE SNILGAFCDM NDVEVPLHLL RYVCLFCGKN 240
GLSLMKDCFE YGTPETLPFL IAHAFITVVS NIRIWLHIPA VMQHIIPFRT YVIRYLCKLS 300
DQELRQSAAR NMADLMWSTV KEPLDTTLCF DKESLDLAFK YFMSPTLTMR LAGLSQITNQ 360
LHTFNDVCNN ESLVSDTETS IAKELADWLI SNNVVEHIFG PNLHIEIIKQ CQVILNFLAA 420
EGRLSTQHID CIWAAAQLKH CSRYIHDLFP SLIKNLDPVP LRHLLNLVSA LEPGVHTEQT 480
LYLASMLIKA LWNNALAAKA QLSKQSSFAS LLNTNMPIGN KKEEEELRRA APSPWSPAAS 540
PQSSDNSDTH QSGASDIEMD EQLINRNKHV QQRLSDTEES MQGSSDETAN SGEDGSSGPG 600
SSSGHSDGSS NEVNSSHASQ SAGSPGSEVQ SEDIADIEAL KEEEEEEEEE EEEEEEEDDE 660
EEEDEEEDDD DDDDHGHNPA KNTCGTELRN RKLENPAGIC LGESQGTSER NGTNSGTGKD 720
LVFNTEPLPS VDNRIRMLDA CAHSEDPEHG ISGEVSSAHL AQGSQEACIT RSGDFLGETI 780
GNELFNCRQF IGPQHHHHHH HHHHHHHHHH HHHHHHHDGH MVDDMLSADD VSCSSSQVSA 840
KSEKNMADFD GEESGCEEEL VQINSHAELT SHLQQHLPNL ASIYHEHLSQ GPAVHKHQFS 900
SNAVTDINLD NVCKKGNTLL WDIVQDDDAI NLSEGLINEA EKLLCSLVCW FTDRQIRMRF 960
IEGCLENLGN NRSVVISLRL LPKLFGTFQQ FGSSYDTHWI TMWAEKELNM MKLFFDNLVY 1020
YIQGIREGRQ KHALYSHSAE VQVRLQFLTC VFSTLGSPDH FRLSLEQVDI LWHCLVEDSE 1080
CYDDALHWFL NQVRSKDQHA MGMETYKHLF LEKMPQLKPE TISMTGLNLF QHLCNLARLA 1140
TSAYDGGSNS ELCGMDQFWG IALRAQSGDV SRAAIQYINS YYINGKTGLE KEQEFISKCM 1200
ESLMIASSSL EQESHSSLTV IERGLLMLKT HLEAFRRRFA YHLRQWQIEG TGISSHLKAL 1260
SDKQSLPLRV VCQPAGLPDK MTIEMYPSDQ VADLRAEVTH WYENLQKEQI NQQAQLQEFG 1320
QSSRKGEFPG GLMGPVRMIS SGHELTTDYD EKALHELGFK DMQMVFVSLG APRRERKGEG 1380
VQLPASCLPP PQKDNIPMLL LLQEPHLTTL FDLLEMLASF KPPSGKVAVD DSESLKCEEL 1440
HLHAENLSRR VWELLMLLPT CPNMLTAFQN VSDEQSNDGL NWKELLKIKS AHKLLYALEI 1500
IEALGKPNRR IRRESTGSYS DLYPDSDDSS EDQVENSKNS WTCKFVAAGG LQQLLEIFNS 1560
AILEPKEQES WTVWQLDCLA CLLKLICQFA VDPSDLDLAY HDVFAWSGIA ESHRKRTWPG 1620
KSRKAAGDHA KSLHIPRLTE VFLVLVQGTS LIQRLMSVAY TYDNLAPRVL KAQSDHRSRH 1680
EVSHYSMWLL VSWAHCCSLV KSSLADSDHL QDWLKQLTLL IPETAVRHES CNGLYKLSLS 1740
GLDGGDSIHR SFLLLAASTL LKFLPDAQAL KPPRIDDYEE EPLLKPGCKE YFWLLCKLVD 1800
NIHIKDASQT TLLDLDALAR HLADCIRSRE ILDHLDGSIE DDGLSGLLRL ATSVIKHKPP 1860
FKFSREGQEF LRDIFNLLFL LPSLKDRRQP KCKSHSCRAA AYDLLVEMVK GSVENYRLIH 1920
NWVMAQHMQS HAPYKWDYWP HEDVRAECRF VGLTNLGATC YLASTIQQLY MIPEARQAVF 1980
TAKYSEDMKH KTTLLELQKM FTYLMESECK AYNPRPFCKT YTMDKQPLNT GEQKDMTEFF 2040
TDLITKVEEM SPELKNTVKS LFGGVITNNV VSLDCEHVSQ TAEEFYTVRC QVADMKNIYE 2100
SLDEVTIKDT LEGDNMYTCS HCGKKVRAEK RACFKKLPRI LSFNTMRYTF NMVTMMKEKV 2160
NTHFSFPLRL DMTPYTEDFL MGKSDRKEGF KDVGDRSKDT ESYEYDLIGV TVHTGTADGG 2220
HYYSFIRDIV NPHAYKNNKW YLFNDAEVKP FDSAQLASEC FGGEMTTKTY DSVTDKFMDF 2280
SFEKTHSAYM LFYKRMEPEE ENGREYKFDV SSELLEWIWH DNMQFLQDKN IFEHTYFGFM 2340
WQLCSCIPST LPDPKAVSLM TAKLSTSFVL ETFIHSKEKP TMLQWIELLT KQFNNSQAAC 2400
EWFLDRMADD DWWPMQILIK CPNQIVRQMF QRLCIHVIQR LRPVHAHLYL QPGMEDGSDD 2460
MDASVEDIGG RSCVTRFVRT LLLIMEHGVK PHSKHLTEYF AFLYEFAKMG EEESQFLLSL 2520
QAISTMVHFY MGTKGPENPQ VEVLSEEEGE EEEEEEDILS LAEEKYRPAA LEKMIALVAL 2580
LVEQSRSERH LTLSQTDMAA LTGGKGFPFL FQHIRDGINI RQTCNLIFSL CRYNNRLAEH 2640
IVSMLFTSIA KLTPEAANPF FKLLTMLMEF AGGPPGMPPF ASYILQRIWE VIEYNPSQCL 2700
DWLAVQTPRN KLAHSWVLQN MENWVERFLL AHNYPRVRTS AAYLLVSLIP SNSFRQMFRS 2760
TRSLHIPTRD LPLSPDTTVV LHQVYNVLLG LLSRAKLYVD AAVHGTTKLV PYLSFMTYCL 2820
ISKTEKLMFS TYFMDLWNLF QPKLSEPAIA TNHNKQALLS FWYNVCADCP ENIRLIVQNP 2880
VVTKNIAFNY ILADHDDQDV VLFNRGMLPA YYGILRLCCE QSPAFTRQLA SHQNIQWAFK 2940
NLTPHASQYP GAVEELFNLM QLFIAQRPDM REEELEDIKQ FKKTTISCYL RCLDGRSCWT 3000
TLISAFRILL ESDEDRLLVV FNRGLILMTE SFNTLHMMYH EATACHVTGD LVELLSIFLS 3060
VLKSTRPYLQ RKDVKQALIQ WQERIEFAHK LLTLLNSYSP PELRNACIDV LKELVLLSPH 3120
DFLHTLVPFL QHNHCTYHHS NIPMSLGPYF PCRENIKLIG GKSNIRPPRP ELNMCLLPTM 3180
VETSKGKDDV YDRMLLDYFF SYHQFIHLLC RVAINCEKFT ETLVKLSVLV AYEGLPLHLA 3240
LFPKLWTELC QTQSAMSKNC IKLLCEDPVF AEYIKCILMD ERTFLNNNIV YTFMTHFLLK 3300
VQSQVFSEAN CASLISTLIT NLINQYQNLQ SDFTNRVEIS KASAALNGDL RALALLLSVH 3360
TPKQLNPALI PTLQELLNKC RTCLQQRNSL QEQEAKERKT KDDEGATPVK RRRVSSDEEH 3420
TVDSCIGDIK TETREVLTPT STSDNETRDS SIIDPGTEQD LPSPENSSVK EYRMEGPSSF 3480
SEDGSHIRSQ HAEEQSNNGR FDDCKEFKDH CSKDTTLAED ESEFPSTSIS AVLSDLADLR 3540
SCDGQALSSQ DPEAAVSLSC GHSRGLISHM QQHDILDTLC RTIESTIHVV TRISGKGNQA 3600
AS 3602 
Gene Ontology
 GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19. 
Pfam
 PF00443; UCH 
SMART
  
PROSITE
 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3 
PRINTS