| Tag | Content |
|---|
| CPLM ID | CPLM-023298 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Wiskott-Aldrich syndrome protein family member 3 |
Protein Synonyms/Alias | WASP family protein member 3; Protein WAVE-3; Verprolin homology domain-containing protein 3 |
Gene Name | WASF3 |
Gene Synonyms/Alias | KIAA0900; SCAR3; WAVE3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 162 | SYFFDLWKEKMLQDT | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. |
Sequence Annotation | DOMAIN 440 457 WH2.
MOD_RES 151 151 Phosphotyrosine; by ABL1.
MOD_RES 248 248 Phosphotyrosine; by ABL1.
MOD_RES 337 337 Phosphotyrosine; by ABL1.
MOD_RES 486 486 Phosphotyrosine; by ABL1. |
Keyword | Actin-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 502 AA |
Protein Sequence | MPLVKRNIEP RHLCRGALPE GITSELECVT NSTLAAIIRQ LSSLSKHAED IFGELFNEAN 60
NFYIRANSLQ DRIDRLAVKV TQLDSTVEEV SLQDINMKKA FKSSTVQDQQ VVSKNSIPNP 120
VADIYNQSDK PPPLNILTPY RDDKKDGLKF YTDPSYFFDL WKEKMLQDTE DKRKEKRRQK 180
EQKRIDGTTR EVKKVRKARN RRQEWNMMAY DKELRPDNRL SQSVYHGASS EGSLSPDTRS 240
HASDVTDYSY PATPNHSLHP QPVTPSYAAG DVPPHGPASQ AAEHEYRPPS ASARHMALNR 300
PQQPPPPPPP QAPEGSQASA PMAPADYGML PAQIIEYYNP SGPPPPPPPP VIPSAQTAFV 360
SPLQMPMQPP FPASASSTHA APPHPPSTGL LVTAPPPPGP PPPPPGPPGP GSSLSSSPMH 420
GPPVAEAKRQ EPAQPPISDA RSDLLAAIRM GIQLKKVQEQ REQEAKREPV GNDVATILSR 480
RIAVEYSDSD DDSEFDENDW SD 502 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0030027; C:lamellipodium; IEA:Compara. GO:0030041; P:actin filament polymerization; TAS:ProtInc. GO:0030032; P:lamellipodium assembly; IEA:Compara. GO:0014003; P:oligodendrocyte development; IEA:Compara. GO:0031643; P:positive regulation of myelination; IEA:Compara. GO:0008360; P:regulation of cell shape; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |