CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036911
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Septin-7 
Protein Synonyms/Alias
  
Gene Name
 SEPT7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
87PGPSHRIKKTVQVEQubiquitination[1]
88GPSHRIKKTVQVEQSubiquitination[1, 2]
96TVQVEQSKVLIKEGGubiquitination[1, 2]
185FMKRLHEKVNIIPLIubiquitination[1, 2]
194NIIPLIAKADTLTPEubiquitination[1]
207PEECQQFKKQIMKEIacetylation[2]
207PEECQQFKKQIMKEIubiquitination[1, 3]
212QFKKQIMKEIQEHKIubiquitination[1, 2]
234TDDEEENKLVKKIKDacetylation[4]
234TDDEEENKLVKKIKDubiquitination[1, 2, 5, 6]
237EEENKLVKKIKDRLPubiquitination[1]
238EENKLVKKIKDRLPLubiquitination[1, 2]
259TIIEVNGKRVRGRQYubiquitination[2]
297RTHMQDLKDVTNNVHubiquitination[1, 2, 3, 6]
312YENYRSRKLAAVTYNubiquitination[1]
327GVDNNKNKGQLTKSPubiquitination[1]
332KNKGQLTKSPLAQMEubiquitination[1, 2]
372KEKVQKLKDSEAELQubiquitination[1]
394KNLEAQHKELEEKRRacetylation[2]
394KNLEAQHKELEEKRRubiquitination[6]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTP-binding; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 436 AA 
Protein Sequence
MSVSARSAAA EERSVNSSTM GQQKNLEGYV GFANLPNQVY RKSVKRGFEF TLMVVGESGL 60
GKSTLINSLF LTDLYSPEYP GPSHRIKKTV QVEQSKVLIK EGGVQLLLTI VDTPGFGDAV 120
DNSNCWQPVI DYIDSKFEDY LNAESRVNRR QMPDNRVQCC LYFIAPSGHG LKPLDIEFMK 180
RLHEKVNIIP LIAKADTLTP EECQQFKKQI MKEIQEHKIK IYEFPETDDE EENKLVKKIK 240
DRLPLAVVGS NTIIEVNGKR VRGRQYPWGV AEVENGEHCD FTILRNMLIR THMQDLKDVT 300
NNVHYENYRS RKLAAVTYNG VDNNKNKGQL TKSPLAQMEE ERREHVAKMK KMEMEMEQVF 360
EMKVKEKVQK LKDSEAELQR RHEQMKKNLE AQHKELEEKR RQFEDEKANW EAQQRILEQQ 420
NSSRTLEKNK KKGKIF 436 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0031105; C:septin complex; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:InterPro. 
Interpro
 IPR000038; Cell_div_GTP-bd.
 IPR027417; P-loop_NTPase.
 IPR016491; Septin.
 IPR008115; Septin7. 
Pfam
 PF00735; Septin 
SMART
  
PROSITE
  
PRINTS
 PR01742; SEPTIN7.