UniProt Accession

 GALE_MOUSE; Q8R059 

Genbank Protein ID

 BC027438 

Genbank Nucleotide ID

 AAH27438.1 

Protein Name

 UDP-glucose 4-epimerase 

Protein Synonyms/Alias

 Galactowaldenase; UDP-galactose 4-epimerase 

Gene Name

 Gale 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
77	AALQHLFKKHSFKAV	acetylation	[1]
77	AALQHLFKKHSFKAV	ubiquitination	[2]

Reference

 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. 

Sequence Annotation

 NP_BIND 4 35 NAD (By similarity).
 ACT_SITE 156 156 Proton acceptor (By similarity).
 BINDING 131 131 Substrate (By similarity).  

Keyword

 Carbohydrate metabolism; Complete proteome; Galactose metabolism; Isomerase; NAD; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 347 AA 

Protein Sequence

Gene Ontology

 GO:0050662; F:coenzyme binding; IEA:InterPro.
 GO:0003978; F:UDP-glucose 4-epimerase activity; IDA:MGI.
 GO:0044237; P:cellular metabolic process; IEA:InterPro.
 GO:0019388; P:galactose catabolic process; IEA:Compara.
 GO:0006012; P:galactose metabolic process; IDA:MGI. 

Interpro

 IPR025308; Epimerase_C.
 IPR001509; Epimerase_deHydtase.
 IPR005886; GalE.
 IPR016040; NAD(P)-bd_dom.
 IPR008089; Nuc_sugar_epim. 

Pfam

 PF01370; Epimerase
 PF13950; Epimerase_Csub 

SMART

  

PROSITE

  

PRINTS

 PR01713; NUCEPIMERASE.