CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016427
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Wiskott-Aldrich syndrome protein family member 2 
Protein Synonyms/Alias
 WASP family protein member 2; Protein WAVE-2 
Gene Name
 Wasf2 
Gene Synonyms/Alias
 Wave2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
85KVTQLDPKEEEVSLQubiquitination[1]
161SYFFDLWKEKMLQDTubiquitination[1]
216GQEFVESKERLGPSGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). 
Sequence Annotation
 DOMAIN 435 452 WH2.  
Keyword
 Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 497 AA 
Protein Sequence
MPLVTRNIEP RHLCRQTLPS DTSELECRTN ITLANVIRQL GSLSKYAEDI FGEICTQASA 60
FASRVNSLAE RVDRVQVKVT QLDPKEEEVS LQGINTRKAF RSSTTQDQKL FDRNSLPVPV 120
LETYNSCDAP PPLNNLSPYR DDGKEALKFY TNPSYFFDLW KEKMLQDTKD IMKEKRKHRK 180
EKKDNPNRGN VNPRKIKTRK EEWEKMKMGQ EFVESKERLG PSGYSSTLVY QNGSIGSVEN 240
VDAASYPPPP QSDSASSPSP SFSEDNLPPP PAEFSYPADN QRGSVLAGPK RTSMVSPSHP 300
PPAPPLSSPP GPKPGFAPPP APPPPPPMSV PPPLPSMGFG SPGTPPPPSP PSFPPHPDFA 360
APPPPPPPPA ADYPMPPPPL SQPSGGAPPP PPPPPPPGPP PLPFSGADGQ PAAPPPPPPS 420
EATKPKSSLP AVSDARSDLL SAIRQGFQLR RVEEQREQEK RDVVGNDVAT ILSRRIAVEY 480
SDSEDDSSEF DEDDWSD 497 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005769; C:early endosome; IDA:MGI.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0001726; C:ruffle; IDA:MGI.
 GO:0030036; P:actin cytoskeleton organization; IMP:MGI.
 GO:0030048; P:actin filament-based movement; IMP:MGI.
 GO:0001667; P:ameboidal cell migration; IMP:MGI.
 GO:0001525; P:angiogenesis; IMP:MGI.
 GO:0006897; P:endocytosis; IDA:MGI.
 GO:0030032; P:lamellipodium assembly; IMP:MGI.
 GO:0072673; P:lamellipodium morphogenesis; IMP:MGI.
 GO:0035855; P:megakaryocyte development; IMP:MGI.
 GO:0016601; P:Rac protein signal transduction; IMP:MGI. 
Interpro
 IPR003124; WH2_dom. 
Pfam
 PF02205; WH2 
SMART
 SM00246; WH2 
PROSITE
 PS51082; WH2 
PRINTS