UniProt Accession

 B7ZA04_HUMAN; B7ZA04 

Genbank Protein ID

 AC064826; AC068039; AK316119 

Genbank Nucleotide ID

 BAH14490.1 

Protein Name

 Cytoplasmic dynein 1 intermediate chain 2 

Protein Synonyms/Alias

 cDNA, FLJ79018, highly similar to Cytoplasmic dynein 1 intermediate chain 2 

Gene Name

 DYNC1I2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
55	QEESDLEKKRREAEA	acetylation	[1]
129	GSRRGPIKLGMAKIT	ubiquitination	[2]
247	SGRDLEDKEGEIQAG	ubiquitination	[3]
422	ELVHKQSKAVAVTSM	ubiquitination	[2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 630 AA 

Protein Sequence

Gene Ontology

 GO:0005868; C:cytoplasmic dynein complex; IEA:InterPro.
 GO:0007018; P:microtubule-based movement; IEA:InterPro. 

Interpro

 IPR025956; Dynein_IC_1/2.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF11540; Dynein_IC2
 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS50294; WD_REPEATS_REGION 

PRINTS