| Tag | Content |
|---|
| CPLM ID | CPLM-020466 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lysine-specific histone demethylase 1 homolog 3 |
Protein Synonyms/Alias | Flavin-containing amine oxidase domain-containing protein 3; Protein FLOWERING LOCUS D; Protein LSD1-LIKE 3; Protein SUPPRESSOR OF OVEREXPRESSED FCA 1 |
Gene Name | FLD |
Gene Synonyms/Alias | SOF1; At3g10390; F13M14.34; F14P13.1 |
Created Date | July 27, 2013 |
Organism | Arabidopsis thaliana (Mouse-ear cress) |
NCBI Taxa ID | 3702 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 287 | VDPDVDIKVEVAFNQ | sumoylation | [1] | | 693 | RKRNEDPKADQHSNK | sumoylation | [1] | | 770 | DSVIASIKAERTGRK | sumoylation | [1] |
|
Reference | [1] The SUMO E3 ligase, AtSIZ1, regulates flowering by controlling a salicylic acid-mediated floral promotion pathway and through affects on FLC chromatin structure. Jin JB, Jin YH, Lee J, Miura K, Yoo CY, Kim WY, Van Oosten M, Hyun Y, Somers DE, Lee I, Yun DJ, Bressan RA, Hasegawa PM. Plant J. 2008 Feb;53(3):530-40. [ PMID: 18069938] |
Functional Description | Probable histone demethylase that promotes flowering independently of the photoperiod and vernalization pathways by repressing FLOWERING LOCUS C (FLC), a floral repressor that blocks the transition from vegetative to reproductive development. Probably mediates histone H3 'Lys-4' demethylation at FLC locus. Seems to act in partial redundancy with LDL1 and LDL2 to repress FLC expression. Required for histone H4 deacetylation of FLC locus. May be a component of the histone deacetylase complex. |
Sequence Annotation | DOMAIN 76 177 SWIRM.
BINDING 214 214 FAD (By similarity).
BINDING 216 216 FAD (By similarity).
BINDING 222 222 FAD (By similarity).
BINDING 595 595 FAD (By similarity).
CROSSLNK 287 287 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 693 693 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 770 770 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Chromatin regulator; Complete proteome; FAD; Flavoprotein; Isopeptide bond; Oxidoreductase; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 789 AA |
Protein Sequence | MVSFSAPKKR RRGRSQRSMS SLNSLPVPNV GLLPGNSNFV SSSASSSGRF NVEVVNGSNQ 60
TVKSYPGIGD EIITINKEAT TEALLALTAG FPADSLTEEE IEFGVVPIVG GIEQVNYILI 120
RNHIISKWRE NISSWVTKEM FLNSIPKHCS SLLDSAYNYL VTHGYINFGI AQAIKDKFPA 180
QSSKSSVIIV GAGLSGLAAA RQLMRFGFKV TVLEGRKRPG GRVYTKKMEA NRVGAAADLG 240
GSVLTGTLGN PLGIIARQLG SSLYKVRDKC PLYRVDGKPV DPDVDIKVEV AFNQLLDKAS 300
KLRQLMGDVS MDVSLGAALE TFRQVSGNDV ATEEMGLFNW HLANLEYANA GLVSKLSLAF 360
WDQDDPYDMG GDHCFLPGGN GRLVQALAEN VPILYEKTVQ TIRYGSNGVK VTAGNQVYEG 420
DMVLCTVPLG VLKNGSIKFV PELPQRKLDC IKRLGFGLLN KVAMLFPYVF WSTDLDTFGH 480
LTEDPNYRGE FFLFYSYAPV AGGALLIALV AGEAAHKFET MPPTDAVTRV LHILRGIYEP 540
QGINVPDPLQ TVCTRWGGDP FSLGSYSNVA VGASGDDYDI LAESVGDGRL FFAGEATTRR 600
YPATMHGAFV TGLREAANMA QSAKARGIRK RIDRNPSRNA HSCAILLADL FRDPDLEFGS 660
FCIIFSRRNP DPKSPAILRV TLSEPRKRNE DPKADQHSNK ILFQQLQSHF NQQQQIQVYT 720
LLTRQQALDL REVRGGDEKR LYYLCETLGV KLVGRKGLGV GADSVIASIK AERTGRKLPS 780
SSTSGTKSG 789 |
Gene Ontology | GO:0003677; F:DNA binding; IEA:InterPro. GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. GO:0016568; P:chromatin modification; IEA:UniProtKB-KW. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |