CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021105
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleolar and spindle-associated protein 1 
Protein Synonyms/Alias
 NuSAP 
Gene Name
 Nusap1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
356LSRPLNYKPHKGKLKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Microtubule-associated protein with the capacity to bundle and stabilize microtubules. May associate with chromosomes and promote the organization of mitotic spindle microtubules around them. 
Sequence Annotation
 REGION 243 367 Interaction with microtubules.
 MOTIF 369 375 KEN box (By similarity).
 MOD_RES 139 139 Phosphoserine (By similarity).
 MOD_RES 191 191 Phosphothreonine (By similarity).
 MOD_RES 246 246 Phosphoserine (By similarity).
 MOD_RES 250 250 Phosphothreonine (By similarity).
 MOD_RES 323 323 Phosphothreonine (By similarity).
 MOD_RES 337 337 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Cell cycle; Cell division; Chromosome; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; DNA-binding; Microtubule; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 427 AA 
Protein Sequence
MTVPSAEELD SFKYSDLQNL AKRLGLRANM KADKLLKALK AHLNPETRKE NKNQDENQFS 60
TDETEIHVSS EEQAETESGG HVTKTRRRRR KKHKTIHGIP TSQTLLQDHL EMKGTDSSNF 120
QNQENQENQD PRDTAEVPSL PEQRPEDGNA ASSGEGEVND IKDSKKPLEK RSLCTDEFSK 180
LGNNKRTSAT TPNFKKLHEA RFKKMESIDE YIMRKKKHLK EHSSLNELKL DKKGIVTPVP 240
PRGRLSVPCT PARQQCPQGH SATKMNVRFS AATKDNEHKC SLTKTPARKS PHVTAPGSAS 300
KGQAVFRTPK SKATERTSIA VITPFKLMTE ATQTPSSSKK PVFDLKASLS RPLNYKPHKG 360
KLKPWGQAKE NNSLNERVSR VTFHRKTYKQ PHLQTREERW KRQEQERKEK KEKLLEARRN 420
LGVTKAQ 427 
Gene Ontology
 GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IDA:MGI.
 GO:0005876; C:spindle microtubule; IDA:MGI.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008017; F:microtubule binding; IDA:MGI.
 GO:0040001; P:establishment of mitotic spindle localization; ISA:MGI.
 GO:0007076; P:mitotic chromosome condensation; ISA:MGI.
 GO:0000281; P:mitotic cytokinesis; ISA:MGI.
 GO:0045840; P:positive regulation of mitosis; ISA:MGI. 
Interpro
 IPR026756; NuSAP. 
Pfam
  
SMART
  
PROSITE
  
PRINTS