CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039948
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein phosphatase Slingshot homolog 2 
Protein Synonyms/Alias
  
Gene Name
 SSH2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
292LREIMMQKDLENITSubiquitination[1]
300DLENITSKEIRTELEubiquitination[1]
450DRAYDYVKERRTVTKubiquitination[1]
477QGILLASKQRHNKLWubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1450 AA 
Protein Sequence
MALVTVQRSP TPSTTSSPCA SSSHLEDSES AALLCCECEE SEIFTDSNEA DSGEEECRSQ 60
PRSISESFLT VKGAALFLPR GNGSSTPRIS HRRNKHAGDL QQHLQAMFIL LRPEDNIRLA 120
VRLESTYQNR TRYMVVVSTN GRQDTEESIV LGMDFSSNDS STCTMGLVLP LWSDTLIHLD 180
GDGGFSVSTD NRVHIFKPVS VQAMWSALQS LHKACEVARA HNYYPGSLFL TWVSYYESHI 240
NSDQSSVNEW NAMQDVQSHR PDSPALFTDI PTERERTERL IKTKLREIMM QKDLENITSK 300
EIRTELEMQM VCNLREFKEF IDNEMIVILG QMDSPTQIFE HVFLGSEWNA SNLEDLQNRG 360
VRYILNVTRE IDNFFPGVFE YHNIRVYDEE ATDLLAYWND TYKFISKAKK HGSKCLVHCK 420
MGVSRSASTV IAYAMKEYGW NLDRAYDYVK ERRTVTKPNP SFMRQLEEYQ GILLASKQRH 480
NKLWRSHSDS DLSDHHEPIC KPGLELNKKD ITTSADQIAE VKTMESHPPI PPVFVEHMVP 540
QDANQKGLCT KERMICLEFT SREFHAGQIE DELNLNDING CSSGCCLNES KFPLDNCHAS 600
KALIQPGHVP EMANKFPDLT VEDLETDALK ADMNVHLLPM EELTSPLKDP PMSPDPESPS 660
PQPSCQTEIS DFSTDRIDFF SALEKFVELS QETRSRSFSH SRMEELGGGR NESCRLSVVE 720
VAPSKVTADD QRSSSLSNTP HASEESSMDE EQSKAISELV SPDIFMQSHS ENAISVKEIV 780
TEIESISQGV GQIQLKGDIL PNPCHTPKKN SIHELLLERA QTPENKPGHM EQDEDSCTAQ 840
PELAKDSGMC NPEGCLTTHS SIADLEEGEP AEGEQELQGS GMHPGAKWYP GSVRRATLEF 900
EERLRQEQEH HGAAPTCTSL STRKNSKNDS SVADLAPKGK SDEAPPEHSF VLKEPEMSKG 960
KGKYSGSEAG SLSHSEQNAT VPAPRVLEFD HLPDPQEGPG SDTGTQQEGV LKDLRTVIPY 1020
QESETQAVPL PLPKRVEIIE YTHIVTSPNH TGPGSEIATS EKSGEQGLRK VNMEKSVTVL 1080
CTLDENLNRT LDPNQVSLHP QVLPLPHSSS PEHNRPTDHP TSILSSPEDR GSSLSTALET 1140
AAPFVSHTTH LLSASLDYLH PQTMVHLEGF TEQSSTTDEP SAEQVSWEES QESPLSSGSE 1200
VPYKDSQLSS ADLSLISKLG DNTGELQEKM DPLPVACRLP HSSSSENIKS LSHSPGVVKE 1260
RAKEIESRVV FQAGLTKPSQ MRRSASLAKL GYLDLCKDCL PEREPASCES PHLKLLQPFL 1320
RTDSGMHAME DQESLENPGA PHNPEPTKSF VEQLTTTECI VQSKPVERPL VQYAKEFGSS 1380
QQYLLPRAGL ELTSSEGGLP VLQTQGLQCA CPAPGLAVAP RQQHGRTHPL RRLKKANDKK 1440
RTTNPFYNTM 1450 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
 GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. 
Interpro
 IPR014876; DEK_C.
 IPR000340; Dual-sp_phosphatase_cat-dom.
 IPR020422; Dual-sp_phosphatase_subgr_cat.
 IPR024950; DUSP.
 IPR009057; Homeodomain-like.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS. 
Pfam
 PF08766; DEK_C
 PF00782; DSPc 
SMART
 SM00195; DSPc 
PROSITE
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50054; TYR_PHOSPHATASE_DUAL 
PRINTS