UniProt Accession

 ILKAP_MOUSE; Q8R0F6; Q05CC3 

Genbank Protein ID

 BC026953; BC027439 

Genbank Nucleotide ID

 AAH26953.1; AAH27439.1 

Protein Name

 Integrin-linked kinase-associated serine/threonine phosphatase 2C 

Protein Synonyms/Alias

 ILKAP 

Gene Name

 Ilkap 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
161	HGGIRASKFAAQNLH	ubiquitination	[1]
185	GDIISVEKTVKRCLL	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation (By similarity). 

Sequence Annotation

 DOMAIN 128 390 PP2C-like.
 METAL 152 152 Manganese 1 (By similarity).
 METAL 152 152 Manganese 2 (By similarity).
 METAL 153 153 Manganese 1; via carbonyl oxygen (By
 METAL 326 326 Manganese 2 (By similarity).
 METAL 381 381 Manganese 2 (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 210 210 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Manganese; Metal-binding; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 392 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004722; F:protein serine/threonine phosphatase activity; IEA:Compara.
 GO:0045786; P:negative regulation of cell cycle; IEA:Compara.
 GO:0006470; P:protein dephosphorylation; IEA:Compara. 

Interpro

 IPR001932; PP2C-like.
 IPR000222; PP2C_Mn2_Asp60_BS.
 IPR015655; Protein_Pase_2C. 

Pfam

 PF00481; PP2C 

SMART

 SM00331; PP2C_SIG
 SM00332; PP2Cc 

PROSITE

 PS01032; PP2C 

PRINTS