UniProt Accession

 CATH_RAT; P00786 

Genbank Protein ID

 Y00708; BC085352; M38135 

Genbank Nucleotide ID

 CAA68699.1; AAH85352.1; AAA63484.1 

Protein Name

 Pro-cathepsin H 

Protein Synonyms/Alias

 Cathepsin H mini chain; Cathepsin H; Cathepsin H heavy chain; Cathepsin H light chain 

Gene Name

 Ctsh 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
218	QCKFNPEKAVAFVKN	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Important for the overall degradation of proteins in lysosomes. 

Sequence Annotation

 ACT_SITE 139 139 By similarity.
 ACT_SITE 279 279 By similarity.
 ACT_SITE 299 299 By similarity.
 CARBOHYD 228 228 N-linked (GlcNAc...).
 DISULFID 100 325 By similarity.
 DISULFID 136 179 By similarity.
 DISULFID 170 212 By similarity.
 DISULFID 270 320 By similarity.  

Keyword

 Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Protease; Reference proteome; Signal; Thiol protease; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 333 AA 

Protein Sequence

Gene Ontology

 GO:0001669; C:acrosomal vesicle; IDA:RGD.
 GO:0097208; C:alveolar lamellar body; ISS:UniProtKB.
 GO:0035085; C:cilium axoneme; IDA:RGD.
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005615; C:extracellular space; ISS:UniProtKB.
 GO:0005764; C:lysosome; ISS:UniProtKB.
 GO:0001520; C:outer dense fiber; IDA:RGD.
 GO:0004177; F:aminopeptidase activity; IDA:RGD.
 GO:0016505; F:apoptotic protease activator activity; ISS:UniProtKB.
 GO:0004197; F:cysteine-type endopeptidase activity; ISS:UniProtKB.
 GO:0030108; F:HLA-A specific activating MHC class I receptor activity; ISS:UniProtKB.
 GO:0043621; F:protein self-association; IDA:RGD.
 GO:0004252; F:serine-type endopeptidase activity; ISS:UniProtKB.
 GO:0070324; F:thyroid hormone binding; ISS:UniProtKB.
 GO:0010815; P:bradykinin catabolic process; ISS:UniProtKB.
 GO:0097067; P:cellular response to thyroid hormone stimulus; IEP:UniProtKB.
 GO:0060448; P:dichotomous subdivision of terminal units involved in lung branching; ISS:UniProtKB.
 GO:0070371; P:ERK1 and ERK2 cascade; ISS:UniProtKB.
 GO:0002764; P:immune response-regulating signaling pathway; ISS:UniProtKB.
 GO:0033619; P:membrane protein proteolysis; ISS:UniProtKB.
 GO:0001656; P:metanephros development; IEP:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
 GO:0010813; P:neuropeptide catabolic process; ISS:UniProtKB.
 GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
 GO:0010634; P:positive regulation of epithelial cell migration; ISS:UniProtKB.
 GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
 GO:0031648; P:protein destabilization; ISS:UniProtKB.
 GO:0032526; P:response to retinoic acid; ISS:UniProtKB.
 GO:0007283; P:spermatogenesis; IEP:RGD.
 GO:0043129; P:surfactant homeostasis; ISS:UniProtKB.
 GO:0001913; P:T cell mediated cytotoxicity; ISS:UniProtKB.
 GO:0031638; P:zymogen activation; ISS:UniProtKB. 

Interpro

 IPR025661; Pept_asp_AS.
 IPR000169; Pept_cys_AS.
 IPR025660; Pept_his_AS.
 IPR013128; Peptidase_C1A.
 IPR000668; Peptidase_C1A_C.
 IPR013201; Prot_inhib_I29. 

Pfam

 PF08246; Inhibitor_I29
 PF00112; Peptidase_C1 

SMART

 SM00848; Inhibitor_I29
 SM00645; Pept_C1 

PROSITE

 PS00640; THIOL_PROTEASE_ASN
 PS00139; THIOL_PROTEASE_CYS
 PS00639; THIOL_PROTEASE_HIS 

PRINTS

 PR00705; PAPAIN.