UniProt Accession

 UBX2B_HUMAN; Q14CS0; B3KWZ3 

Genbank Protein ID

 AK126300; BC113645 

Genbank Nucleotide ID

 BAG54305.1; AAI13646.1 

Protein Name

 UBX domain-containing protein 2B 

Protein Synonyms/Alias

 NSFL1 cofactor p37; p97 cofactor p37 

Gene Name

 UBXN2B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
40	ELYEDEVKCKSSKSN	ubiquitination	[1]
55	RPKATVFKSPRTPPQ	ubiquitination	[1]
83	IVRPSTGKIVNELFK	ubiquitination	[1]
90	KIVNELFKEAREHGA	ubiquitination	[1]
128	RLGSSFCKRSEYIYG	ubiquitination	[1]
176	AQFLESVKRGEIPLE	ubiquitination	[1, 2]
207	HQDQEYIKPRLRFKA	ubiquitination	[1]
213	IKPRLRFKAFSGEGQ	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. 

Sequence Annotation

 DOMAIN 141 206 SEP.
 DOMAIN 252 329 UBX.
 MOD_RES 56 56 Phosphoserine.
 MOD_RES 59 59 Phosphothreonine.
 MOD_RES 231 231 Phosphoserine.
 MOD_RES 235 235 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; Endoplasmic reticulum; Golgi apparatus; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 331 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 

Interpro

 IPR012989; SEP_domain.
 IPR001012; UBX. 

Pfam

 PF08059; SEP
 PF00789; UBX 

SMART

 SM00553; SEP
 SM00166; UBX 

PROSITE

 PS51399; SEP
 PS50033; UBX 

PRINTS