UniProt Accession

 RSSA_RAT; P38983; B6ZB78 

Genbank Protein ID

 D25224; FJ386454; BC060578; U04942; M27798 

Genbank Nucleotide ID

 BAA04953.1; ACJ13448.1; AAH60578.1; AAB60453.1; AAA41509.1 

Protein Name

 40S ribosomal protein SA 

Protein Synonyms/Alias

 37 kDa laminin receptor precursor; 37LRP; 37/67 kDa laminin receptor; LRP/LR; 67 kDa laminin receptor; 67LR; Laminin receptor 1; LamR; Laminin-binding protein precursor p40; LBP/p40 

Gene Name

 Rpsa 

Gene Synonyms/Alias

 Lamr1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
52	GIYIINLKRTWEKLL	acetylation	[1]
89	TGQRAVLKFAAATGA	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA (By similarity). 

Sequence Annotation

 REPEAT 230 232 [DE]-W-[ST] 1.
 REPEAT 247 249 [DE]-W-[ST] 2.
 REPEAT 266 268 [DE]-W-[ST] 3.
 REPEAT 275 277 [DE]-W-[ST] 4.
 REPEAT 293 295 [DE]-W-[ST] 5.
 REGION 54 113 Interaction with PPP1R16B (By
 REGION 161 180 Laminin-binding (By similarity).
 REGION 205 229 Laminin-binding (By similarity).
 REGION 242 295 Laminin-binding (By similarity).
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 43 43 Phosphoserine (By similarity).
 MOD_RES 52 52 N6-acetyllysine (By similarity).
 MOD_RES 139 139 Phosphotyrosine (By similarity).  

Keyword

 Acetylation; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Nucleus; Phosphoprotein; Receptor; Reference proteome; Repeat; Ribonucleoprotein; Ribosomal protein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 295 AA 

Protein Sequence

Gene Ontology

 GO:0030686; C:90S preribosome; IBA:RefGenome.
 GO:0005604; C:basement membrane; IDA:RGD.
 GO:0022627; C:cytosolic small ribosomal subunit; IDA:RGD.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0005055; F:laminin receptor activity; TAS:RGD.
 GO:0003735; F:structural constituent of ribosome; IBA:RefGenome.
 GO:0016337; P:cell-cell adhesion; IDA:RGD.
 GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:RefGenome.
 GO:0000461; P:endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:RefGenome.
 GO:0030855; P:epithelial cell differentiation; IEP:RGD.
 GO:0000028; P:ribosomal small subunit assembly; IBA:RefGenome.
 GO:0006407; P:rRNA export from nucleus; IBA:RefGenome.
 GO:0006412; P:translation; IBA:RefGenome. 

Interpro

 IPR027504; 40S_ribosomal_SA.
 IPR001865; Ribosomal_S2.
 IPR018130; Ribosomal_S2_CS.
 IPR027498; Ribosomal_S2_euk.
 IPR005707; Ribosomal_S2_euk/arc.
 IPR023591; Ribosomal_S2_flav_dom. 

Pfam

 PF00318; Ribosomal_S2 

SMART

  

PROSITE

 PS00962; RIBOSOMAL_S2_1
 PS00963; RIBOSOMAL_S2_2 

PRINTS

 PR00395; RIBOSOMALS2.