CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022556
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 319 
Protein Synonyms/Alias
  
Gene Name
 ZNF319 
Gene Synonyms/Alias
 KIAA1388 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
456AHCAAAEKPLRCTLCacetylation[1, 2]
496PDCEKRFKYASDLQRmethylation[3]
543HAREQQFKCVWCGERubiquitination[4, 5]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 ZN_FING 76 100 C2H2-type 1.
 ZN_FING 104 126 C2H2-type 2; degenerate.
 ZN_FING 132 154 C2H2-type 3.
 ZN_FING 202 224 C2H2-type 4.
 ZN_FING 230 252 C2H2-type 5.
 ZN_FING 258 280 C2H2-type 6.
 ZN_FING 287 309 C2H2-type 7; degenerate.
 ZN_FING 315 337 C2H2-type 8.
 ZN_FING 343 365 C2H2-type 9.
 ZN_FING 371 393 C2H2-type 10.
 ZN_FING 399 421 C2H2-type 11; degenerate.
 ZN_FING 428 450 C2H2-type 12.
 ZN_FING 458 480 C2H2-type 13; degenerate.
 ZN_FING 486 508 C2H2-type 14.
 ZN_FING 514 536 C2H2-type 15.
 ZN_FING 542 564 C2H2-type 16.
 MOD_RES 281 281 Phosphoserine.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 582 AA 
Protein Sequence
MSESWQQPPQ TQPQQPQPPQ PQHHAEPPPA LAEHTLPPGT AENPLGCAVY GILLQPDPGL 60
QPPQHAPLQA AGEPGPKCGV CGHDLAHLSS PHEHQCLAGH DRSFQCTQCL KIFHQATDLL 120
EHQCVQAEQK PFVCGVCKMG FSLLTSLAQH HSSHSGLVKC SICEKTYKPA EAAEPATTAA 180
PSLPAAPAPS TVTPAEQADK PYSCPICQKP FKHLSELSRH ERIHTGEKPY KCTLCDKSFS 240
QSSHLVHHKR THSSERPYKC AVCEKTFKHR SHLVRHMYAH SGEHHLFRCN VCELHFKESS 300
ELLQHPCTPS GERPFRCGEC QKAFKRPSDL RQHERTHSAE RPFKCDLCPM GFKQQYALMR 360
HRRTHKTEEP FKCGLCEKGF GQPSHLLYHQ HVHTLETLFK CPVCQKGFDQ SAELLRHKCL 420
PGAAERPFKC PVCNKAYKRA SALQKHQLAH CAAAEKPLRC TLCERRFFSS SEFVQHRCDP 480
AREKPLKCPD CEKRFKYASD LQRHRRVHTG EKPYKCPNCD KAFKQREHLN KHQGVHAREQ 540
QFKCVWCGER FLDVALLQEH SAQHSAAAAA AEGAYQVAAC LP 582 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00096; zf-C2H2 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS