CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014796
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Neuroligin-2 
Protein Synonyms/Alias
  
Gene Name
 Nlgn2 
Gene Synonyms/Alias
 Kiaa1366 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
749ELVSLQLKRGGGVGAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity). Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. 
Sequence Annotation
 MOD_RES 714 714 Phosphoserine.
 CARBOHYD 98 98 N-linked (GlcNAc...).
 CARBOHYD 136 136 N-linked (GlcNAc...) (Potential).
 CARBOHYD 522 522 N-linked (GlcNAc...) (Potential).
 DISULFID 106 141
 DISULFID 317 328
 DISULFID 487 521  
Keyword
 3D-structure; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 836 AA 
Protein Sequence
MWLLALCLVG LAGAQRGGGG PGGGAPGGPG LGLGSLGEER FPVVNTAYGR VRGVRRELNN 60
EILGPVVQFL GVPYATPPLG ARRFQPPEAP ASWPGVRNAT TLPPACPQNL HGALPAIMLP 120
VWFTDNLEAA ATYVQNQSED CLYLNLYVPT EDGPLTKKRD EATLNPPDTD IRDSGKKPVM 180
LFLHGGSYME GTGNMFDGSV LAAYGNVIVV TLNYRLGVLG FLSTGDQAAK GNYGLLDQIQ 240
ALRWLSENIA HFGGDPERIT IFGSGAGASC VNLLILSHHS EGLFQKAIAQ SGTAISSWSV 300
NYQPLKYTRL LAAKVGCDRE DSTEAVECLR RKSSRELVDQ DVQPARYHIA FGPVVDGDVV 360
PDDPEILMQQ GEFLNYDMLI GVNQGEGLKF VEDSAESEDG VSASAFDFTV SNFVDNLYGY 420
PEGKDVLRET IKFMYTDWAD RDNGEMRRKT LLALFTDHQW VAPAVATAKL HADYQSPVYF 480
YTFYHHCQAE GRPEWADAAH GDELPYVFGV PMVGATDLFP CNFSKNDVML SAVVMTYWTN 540
FAKTGDPNQP VPQDTKFIHT KPNRFEEVVW SKFNSKEKQY LHIGLKPRVR DNYRANKVAF 600
WLELVPHLHN LHTELFTTTT RLPPYATRWP PRTPGPGTSG TRRPPPPATL PPESDIDLGP 660
RAYDRFPGDS RDYSTELSVT VAVGASLLFL NILAFAALYY KRDRRQELRC RRLSPPGGSG 720
SGVPGGGPLL PTAGRELPPE EELVSLQLKR GGGVGADPAE ALRPACPPDY TLALRRAPDD 780
VPLLAPGALT LLPSGLGPPP PPPPPSLHPF GPFPPPPPTA TSHNNTLPHP HSTTRV 836 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0009986; C:cell surface; ISS:BHF-UCL.
 GO:0060076; C:excitatory synapse; IC:BHF-UCL.
 GO:0060077; C:inhibitory synapse; IC:BHF-UCL.
 GO:0005887; C:integral to plasma membrane; ISS:BHF-UCL.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0042043; F:neurexin family protein binding; IBA:RefGenome.
 GO:0004872; F:receptor activity; IBA:RefGenome.
 GO:0097116; P:gephyrin clustering; IDA:BHF-UCL.
 GO:0007630; P:jump response; ISS:BHF-UCL.
 GO:0035641; P:locomotory exploration behavior; IMP:BHF-UCL.
 GO:0050885; P:neuromuscular process controlling balance; IMP:BHF-UCL.
 GO:0007158; P:neuron cell-cell adhesion; ISS:BHF-UCL.
 GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential; IMP:BHF-UCL.
 GO:0097151; P:positive regulation of inhibitory postsynaptic membrane potential; IMP:BHF-UCL.
 GO:0051965; P:positive regulation of synapse assembly; ISS:BHF-UCL.
 GO:0032230; P:positive regulation of synaptic transmission, GABAergic; IMP:BHF-UCL.
 GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IMP:BHF-UCL.
 GO:0097119; P:postsynaptic density protein 95 clustering; IDA:BHF-UCL.
 GO:0097104; P:postsynaptic membrane assembly; IDA:BHF-UCL.
 GO:0097105; P:presynaptic membrane assembly; IDA:BHF-UCL.
 GO:0035418; P:protein localization to synapse; IDA:BHF-UCL.
 GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; IMP:BHF-UCL.
 GO:0002087; P:regulation of respiratory gaseous exchange by neurological system process; IGI:MGI.
 GO:0019233; P:sensory perception of pain; IMP:BHF-UCL.
 GO:0035176; P:social behavior; ISS:BHF-UCL.
 GO:0072553; P:terminal button organization; ISS:BHF-UCL.
 GO:0001966; P:thigmotaxis; ISS:BHF-UCL. 
Interpro
 IPR002018; CarbesteraseB.
 IPR019819; Carboxylesterase_B_CS.
 IPR000460; Neuroligin. 
Pfam
 PF00135; COesterase 
SMART
  
PROSITE
 PS00941; CARBOXYLESTERASE_B_2 
PRINTS
 PR01090; NEUROLIGIN.