CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001592
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WNT1-inducible-signaling pathway protein 3 
Protein Synonyms/Alias
 WISP-3; CCN family member 6 
Gene Name
 WISP3 
Gene Synonyms/Alias
 CCN6; UNQ462/PRO790/PRO956 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
262NCEMRKEKRLCYIQPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 Appears to be required for normal postnatal skeletal growth and cartilage homeostasis. 
Sequence Annotation
 DOMAIN 44 117 IGFBP N-terminal.
 DOMAIN 208 253 TSP type-1.
 DOMAIN 268 342 CTCK.
 CARBOHYD 178 178 N-linked (GlcNAc...) (Potential).
 CARBOHYD 308 308 N-linked (GlcNAc...) (Potential).
 DISULFID 268 305 By similarity.
 DISULFID 285 319 By similarity.
 DISULFID 296 335 By similarity.
 DISULFID 299 337 By similarity.
 DISULFID 304 341 By similarity.  
Keyword
 Alternative splicing; Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Growth factor; Polymorphism; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 354 AA 
Protein Sequence
MNKRRLLYPS GWLHGPSDMQ GLLFSTLLLA GLAQFCCRVQ GTGPLDTTPE GRPGEVSDAP 60
QRKQFCHWPC KCPQQKPRCP PGVSLVRDGC GCCKICAKQP GEICNEADLC DPHKGLYCDY 120
SVDRPRYETG VCAYLVAVGC EFNQVHYHNG QVFQPNPLFS CLCVSGAIGC TPLFIPKLAG 180
SHCSGAKGGK KSDQSNCSLE PLLQQLSTSY KTMPAYRNLP LIWKKKCLVQ ATKWTPCSRT 240
CGMGISNRVT NENSNCEMRK EKRLCYIQPC DSNILKTIKI PKGKTCQPTF QLSKAEKFVF 300
SGCSSTQSYK PTFCGICLDK RCCIPNKSKM ITIQFDCPNE GSFKWKMLWI TSCVCQRNCR 360
EPGDIFSELK IL 372 
Gene Ontology
 GO:0005615; C:extracellular space; NAS:UniProtKB.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0001558; P:regulation of cell growth; IEA:InterPro.
 GO:0007165; P:signal transduction; TAS:ProtInc. 
Interpro
 IPR006208; Cys_knot.
 IPR006207; Cys_knot_C.
 IPR000867; IGFBP-like.
 IPR012395; IGFBP_CNN.
 IPR017891; Insulin_GF-bd_Cys-rich_CS.
 IPR000884; Thrombospondin_1_rpt. 
Pfam
 PF00007; Cys_knot
 PF00219; IGFBP
 PF00090; TSP_1 
SMART
 SM00041; CT
 SM00121; IB
 SM00209; TSP1 
PROSITE
 PS01185; CTCK_1
 PS01225; CTCK_2
 PS00222; IGFBP_N_1
 PS51323; IGFBP_N_2
 PS50092; TSP1 
PRINTS