| Tag | Content |
|---|
| CPLM ID | CPLM-004668 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Genome polyprotein |
Protein Synonyms/Alias | prM; Peptide pr; Small envelope protein M; Matrix protein; Envelope protein E; Non-structural protein 1; NS1 |
Gene Name | |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Dengue virus type 2 (strain Thailand/PUO-218/1980) (DENV-2) |
NCBI Taxa ID | 11068 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 227 | TLDFELIKTEAKQPA | sumoylation | [1] | | 573 | QLKLNWFKKGSSIGQ | sumoylation | [1] |
|
Reference | [1] The type 2 dengue virus envelope protein interacts with small ubiquitin-like modifier-1 (SUMO-1) conjugating enzyme 9 (Ubc9). Chiu MW, Shih HM, Yang TH, Yang YL. J Biomed Sci. 2007 May;14(3):429-44. [ PMID: 17265167] |
Functional Description | prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans- Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated (By similarity). |
Sequence Annotation | CARBOHYD 83 83 N-linked (GlcNAc...); by host
CARBOHYD 247 247 N-linked (GlcNAc...); by host
CARBOHYD 333 333 N-linked (GlcNAc...); by host
DISULFID 183 210 By similarity.
DISULFID 240 301 By similarity.
DISULFID 254 285 By similarity.
DISULFID 272 296 By similarity.
DISULFID 365 465 By similarity.
DISULFID 482 513 By similarity. |
Keyword | 3D-structure; Clathrin-mediated endocytosis of virus by host; Cleavage on pair of basic residues; Disulfide bond; Fusion of virus membrane with host endosomal membrane; Fusion of virus membrane with host membrane; Glycoprotein; Host endoplasmic reticulum; Host membrane; Host-virus interaction; Membrane; Secreted; Transmembrane; Transmembrane helix; Viral attachment to host cell; Viral envelope protein; Viral nucleoprotein; Viral penetration into host cytoplasm; Virion; Virus endocytosis by host; Virus entry into host cell. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 679 AA |
Protein Sequence | SAGMIIMLIP TVMAFHLTTR NGEPHMIVSR QEKGKSLLFK TEDGVNMCTL MAMDLGELCE 60
DTITYKCPLL RQNEPEDIDC WCNSTSTWVT YGTCTTTGEH RREKRSVALV PHVGMGLETR 120
TETWMSSEGA WKHAQRIEIW ILRHPGFTIM AAILAYTIGT THFQRALIFI LLTAVAPSMT 180
MRCIGISNRD FVEGVSGGSW VDIVLEHGSC VTTMAKNKPT LDFELIKTEA KQPATLRKYC 240
IEAKLTNTTT ESRCPTQGEP SLNEEQDKRF VCKHSMVDRG WGNGCGLFGK GGIVTCAMFT 300
CKKNMEGKVV QPENLEYTIV VTPHSGEEHA VGNDTGKHGK EIKVTPQSSI TEAELTGYGT 360
VTMECSPRTG LDFNEMVLLQ MENKAWLVHR QWFLDLPLPW LPGADTQGSN WIQKETLVTF 420
KNPHAKKQDV VVLGSQEGAM HTALTGATEI QMSSGNLLFT GHLKCRLRMD KLQLKGMSYS 480
MCTGKFKVVK EIAETQHGTI VIRVQYEGDG SPCKIPFEIM DLEKRHVLGR LITVNPIVTE 540
KDSPVNIEAE PPFGDSYIII GVEPGQLKLN WFKKGSSIGQ MFETTMRGAK RMAILGDTAW 600
DFGSLGGVFT SIGKALHQVF GAIYGAAFSG VSWTMKILIG VIITWIGMNS RSTSLSVSLV 660
LVGIVTLYLG VMVQADSGC 679 |
Gene Ontology | GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0019028; C:viral capsid; IEA:InterPro. GO:0019031; C:viral envelope; IEA:UniProtKB-KW. GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. GO:0003676; F:nucleic acid binding; IEA:UniProtKB-KW. GO:0019062; P:viral attachment to host cell; IEA:UniProtKB-KW. GO:0075512; P:viral entry into host cell via clathrin-mediated endocytosis; IEA:UniProtKB-KW. GO:0019058; P:viral infectious cycle; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |