CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044542
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Myosin phosphatase Rho-interacting protein 
Protein Synonyms/Alias
  
Gene Name
 MPRIP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
188EKRAFPRKRPDLLNFubiquitination[1]
196RPDLLNFKKGWLTKQubiquitination[1]
197PDLLNFKKGWLTKQYubiquitination[1]
202FKKGWLTKQYEDGQWubiquitination[1, 2, 3, 4, 5, 6]
333GEPDPEQKRSRARERubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 844 AA 
Protein Sequence
KKKRKVEPPT PQEPGPAKVA VTSSSSSSSS SSSIPSAEKV PTTKSTLWQE EMRTKDQPDG 60
SSLSPAQSPS QSQPPAASSL REPGLESKEE ESAMSSDRMD CGRKVRVESG YFSLEKTKQD 120
LKAEEQQLPP PLSPPSPSTP NHRRSQVIEK FEALDIEKAE HMETNAVGPS PSSDTRQGRS 180
EKRAFPRKRP DLLNFKKGWL TKQYEDGQWK KHWFVLADQS LRYYRDSVAE EAADLDGEID 240
LSACYDVTEY PVQRNYGFQI HTKEGEFTLS AMTSGIRRNW IQTIMKHVHP TTAPDVTSSL 300
PEEKNKSSCS FETCPRPTEK QEAELGEPDP EQKRSRARER RREGRSKTFD WAEFRPIQQA 360
LAQERVGGVG PADTHEPLRP EAEPGELERE RARRREERRK RFGMLDATDG PGTEDAALRM 420
EVDRSPGLPM SDLKTHNVHV EIEQRWHQVE TTPLREEKQV PIAPVHLSSE DGGDRLSTHE 480
LTSLLEKELE QSQKEASDLL EQNRLLQDQL RVALGREQSA REGYVLQATC ERGFAAMEET 540
HQKKIEDLQR QHQRELEKLR EEKDRLLAEE TAATISAIEA MKNAHREEME RELEKSQRSQ 600
ISSVNSDVEA LRRQYLEELQ SVQRELEVLS EQYSQKCLEN AHLAQALEAE RQALRQCQRE 660
NQELNAHNQE LNNRLAAEIT RLRTLLTGDG GGEATGSPLA QGKDAYELEV LLRVKESEIQ 720
YLKQEISSLK DELQTALRDK KYASDKYKDI YTELSIAKAK ADCDISRLKE QLKAATEALG 780
EKSPDSATVS GYDIMKSKSN PDFLKKDRSC VTRQLRNIRS KSLKEGLTVQ ERLKLFESRD 840
LKKD 844 
Gene Ontology
 GO:0005543; F:phospholipid binding; IEA:InterPro. 
Interpro
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF00169; PH 
SMART
 SM00233; PH 
PROSITE
 PS50003; PH_DOMAIN 
PRINTS