CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028656
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Diacylglycerol kinase zeta 
Protein Synonyms/Alias
 Diacylglycerol kinase zeta, isoform CRA_b 
Gene Name
 Dgkz 
Gene Synonyms/Alias
 mCG_130421 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
498LLVFVNPKSGGNQGAubiquitination[1]
565TLDQLRLKPPPPVAIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Complete proteome; Kinase; Reference proteome; Repeat; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1123 AA 
Protein Sequence
METFFRKHFQ RKARGPGERQ RRSSGVGLPT GKARRRSPAG QASSSLAQRR RSSAQLQGCF 60
PSCGVGTRGA SRRRSSTAPP TCNPRFMVDV VPTLQPVTVG AQLLGAPLLL AGLTSMKEEE 120
EEEGVQEGNE TAEATSDARP GTRTTPFSHQ GTWPLLPMPR CLRRASSHLL PADVECGHTL 180
WGLHGHYRRL SQRWPSGQHP GLGGRSPRAS GAAACPMIPA RVRPLSRRRQ VALRRKSAGP 240
QPWSTLLMKA ITKSGLQHLA PPPPTPGAPC GESEEQIQST VDWSESAVYG EHIWFETNVS 300
GDFCYVGEQH CVAKMLPKSA PRKKCAACKI VVHTQCIKQL EKINFRCKPS FRESGSRNVR 360
EPTFVRHHWV HRRRQDGKCR HCGKGFQQKF TFHSKEIVAI SCSWCKQAYH SKVSCFMMQQ 420
IEEPCSLGVH AAVVIPPTWI LRARRPQNTL KASKKKKRAS FKRRSSKKGP EEGRWRPFII 480
RPTPSPLMKP LLVFVNPKSG GNQGAKIIQS FLWYLNPRQV FDLSQGGPRE ALEMYRKVHN 540
LRILACGGDG TVGWILSTLD QLRLKPPPPV AILPLGTGND LARTLNWGGG YTDEPVSKIL 600
SHVEEGNVVQ LDRWDLRAEP NPEAGPEERD DGATDRLPLD VFNNYFSLGF DAHVTLEFHE 660
SREANPEKFN SRFRNKMFYA GTAFSDFLMG SSKDLAKHIR VVCDGMDLTP KIQDLKPQCI 720
VFLNIPRYCA GTMPWGHPGE HHDFEPQRHD DGYLEVIGFT MTSLAALQVG GHGERLTQCR 780
EVLLTTAKAI PVQVDGEPCK LSASRIRIAL RNQATMVQKA KRRSTAPLHS DQQPVPEQLR 840
IQVSRVSMHD YEALHYDKEQ LKEASVPLGT VVVPGDSDLE LCRAHIERLQ REPDGAGAKS 900
PMCHQLSSKW CFLDATTASR FYRIDRAQEH LNYVTEIAQD EIYILDPELL GASARPDLPT 960
PTSPLPASPC SPTPGSMQGD TALPQGEELI EAAKRNDCCK LQELHRAGGD LMHRDQKSRT 1020
LLHHAVSTGS KEVVRYLLDH APPEILDAVE ENGETCLHQA AALGQRTICH YIVEAGASLM 1080
KTDLQGDTPR QRAEKAQDTE LAAYLENRQH YQMIQREDQE TAV 1123 
Gene Ontology
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0004143; F:diacylglycerol kinase activity; IEA:Compara.
 GO:0004857; F:enzyme inhibitor activity; IDA:MGI.
 GO:0001727; F:lipid kinase activity; IEA:Compara.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0031571; P:mitotic G1 DNA damage checkpoint; IEA:Compara.
 GO:0045930; P:negative regulation of mitotic cell cycle; IEA:Compara.
 GO:0046580; P:negative regulation of Ras protein signal transduction; IMP:MGI.
 GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; IEA:InterPro. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR000756; Diacylglycerol_kin_accessory.
 IPR001206; Diacylglycerol_kinase_cat_dom.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd. 
Pfam
 PF12796; Ank_2
 PF00130; C1_1
 PF00609; DAGK_acc
 PF00781; DAGK_cat 
SMART
 SM00248; ANK
 SM00109; C1
 SM00045; DAGKa
 SM00046; DAGKc 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50146; DAGK 
PRINTS