CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022266
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Spermine oxidase 
Protein Synonyms/Alias
 Polyamine oxidase 1; PAO-1; PAOh1 
Gene Name
 SMOX 
Gene Synonyms/Alias
 C20orf16; SMO; UNQ3039/PRO9854 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
259AHVIQLGKPVRCIHWubiquitination[1]
407PPELWYRKICGFDVLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; FAD; Flavoprotein; Nucleus; Oxidoreductase; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 555 AA 
Protein Sequence
MQSCESSGDS ADDPLSRGLR RRGQPRVVVI GAGLAGLAAA KALLEQGFTD VTVLEASSHI 60
GGRVQSVKLG HATFELGATW IHGSHGNPIY HLAEANGLLE ETTDGERSVG RISLYSKNGV 120
ACYLTNHGRR IPKDVVEEFS DLYNEVYNLT QEFFRHDKPV NAESQNSVGV FTREEVRNRI 180
RNDPDDPEAT KRLKLAMIQQ YLKVESCESS SHSMDEVSLS AFGEWTEIPG AHHIIPSGFM 240
RVVELLAEGI PAHVIQLGKP VRCIHWDQAS ARPRGPEIEP RGEGDHNHDT GEGGQGGEEP 300
RGGRWDEDEQ WSVVVECEDC ELIPADHVIV TVSLGVLKRQ YTSFFRPGLP TEKVAAIHRL 360
GIGTTDKIFL EFEEPFWGPE CNSLQFVWED EAESHTLTYP PELWYRKICG FDVLYPPERY 420
GHVLSGWICG EEALVMEKCD DEAVAEICTE MLRQFTGNPN IPKPRRILRS AWGSNPYFRG 480
SYSYTQVGSS GADVEKLAKP LPYTESSKTA HGSSTKQQPG HLFSSKCPEQ PLDANRGAVK 540
PMQVLFSGEA THRKYYSTTH GALLSGQREA ARLIEMYRDL FQQGT 585 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0052895; F:N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity; IEA:EC.
 GO:0052894; F:norspermine:oxygen oxidoreductase activity; IEA:EC.
 GO:0046592; F:polyamine oxidase activity; IDA:UniProtKB.
 GO:0052901; F:spermine:oxygen oxidoreductase (spermidine-forming) activity; IEA:EC.
 GO:0006596; P:polyamine biosynthetic process; TAS:Reactome.
 GO:0006598; P:polyamine catabolic process; IDA:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0046208; P:spermine catabolic process; IDA:UniProtKB.
 GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. 
Interpro
 IPR002937; Amino_oxidase. 
Pfam
 PF01593; Amino_oxidase 
SMART
  
PROSITE
  
PRINTS