CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045103
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 KIAA0100, isoform CRA_a 
Protein Synonyms/Alias
 UPF0378 protein KIAA0100 
Gene Name
 KIAA0100 
Gene Synonyms/Alias
 hCG_31795 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
412LMGPQSGKSAVSRHSubiquitination[1, 2, 3, 4]
703DEAVGVQKWLKGLHQubiquitination[1, 3, 4]
706VGVQKWLKGLHQGTRubiquitination[2]
755HDNYELMKDESKESAubiquitination[1]
771RLQLLDAKVAALRKQubiquitination[1, 3, 5]
777AKVAALRKQHGELLPubiquitination[2]
787GELLPARKIEELYASubiquitination[2]
1166GKLFNNLKPSKKKLGubiquitination[1, 3]
1384SFSGQPDKGSSGGAYubiquitination[3]
1512RQLWLEVKNIEEHRQubiquitination[1]
1704KSLQDDSKNENLLDLubiquitination[1]
1915TTGIPVVKPRQLIATubiquitination[4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2092 AA 
Protein Sequence
MVLKVDTSES LWHIQISRSR FLLDSDGKRL ICEVSLCKIN SKVLKSGQLE DTCLVELSLA 60
LDLCLKVGIS SRHLTAITVD VWTLHAELHE GLFQSQLLCQ GPSLASKPVP CSEVTENLVE 120
PTLPGLFLLQ QLPDQVKVKM ENTSVVLSMN SQKRHLTWTL KLLQFLYHRD EDQLPLRSFT 180
ANSDMAQMST ELLLEDGLLL SQSRQRIVCL NSLKASVQVT TIDLSASLVL NTCIIHYRHQ 240
EFSHWLHLLA LETQGSSSPV LKQRKKRTFP QILAPIIFST SISNVNISIQ LGDTPPFALG 300
FNSISLDYQH LRPQSIHQRG VLTVDHLCWR VGSDSHIQRA PHPPNMHVWG EALVLDSFTL 360
QGSYNQPLGL SSTQSDTLFL DCTIRGLQVE ASDTCAQCLS RILSLMGPQS GKSAVSRHSS 420
FGESVSLLWK VDLKVEDMNL FTLSALVGAS EVRLDTLTIL GSAETSTVGI QGLVLALVKS 480
VTEKMQPCCK APDIPTPVLS LSMLSITYHS SIRSLEVQCG AGLTLLWSPP DHMYLYQHVL 540
ATLQCRDLLR ATVFPETVPS LALETSGTTS ELEGRAPEPL PPKRLLNLTL EVSTAKLTAF 600
VAEDKFITLA AESVSLSRHG GSLQAYCPEL AAGFDGNSIF NFKEVEVQLL PELEEMILHR 660
NPFPALQTLR NRVWLLSFGS VSVEFPYQYD FSRTLDEAVG VQKWLKGLHQ GTRAWASPSP 720
VPLPPDLLLK VEHFSWVFLD DVFEVKLHDN YELMKDESKE SAKRLQLLDA KVAALRKQHG 780
ELLPARKIEE LYASLERKNI EIYIQRSRRL YGNTPMRRAL LTWSLAGLEL VALADASFHG 840
PEHVVEQVQE LDPGSPFPPE GLDLVIQWCR MLKCNVKSFL VRIRDYPRYL FEIRDWRLMG 900
RLVGTEQSGQ PCSRRRQILH LGLPWGNVAV ERNMPPLKFY HDFHSEIFQY TVVWGPCWDP 960
AWTLIGQCVD LLTKPSADPS PPLPWWDKSR LLFHGDWHMD IEQANLHQLA TEDPYNTTEN 1020
MHWEWSHLSF HWKPGQFVFK GDLDINVRTA SKYDDCCFLH LPDLCMTLDL QWLCHGNPHD 1080
HHSVTLRAPE FLPEVPLGQL HDSYRAFRSE NLNLSIKMDL TRHSGTISQP RILLYSSTLR 1140
WMQNFWATWT SVTRPICRGK LFNNLKPSKK KLGQHYKQLS YTALFPQLQV HYWASFAQQR 1200
GIQIECSQGH VFTRGTQRLI PQAGTVMRRL ISDWSVTQMV SDLSQVTVHL MASPTEENAD 1260
HCLDPLVTKT HLLSLSSLTY QRHSNRTAEE ELSARDGDPT FHTHQLHLVD LRISWTTTNR 1320
DIAFGLYDGY KKAAVLKRNL STEALKGLKI DPQMPAKKPK RGVPTSASAP PRVNTPSFSG 1380
QPDKGSSGGA YMLQKLIEET DRFVVFTEEE SGMSDQLCGI AACQTDDIYN RNCLIELVNC 1440
QMVLRGAETE GCVIVSAAKA QLLQCQHHPA WYGDTLKQKT SWTCLLDGMQ YFATTESSPT 1500
EQDGRQLWLE VKNIEEHRQR SLDSVQELME SGQAVGGMVT TTTDWNQPAE AQQAQQVQRI 1560
ISRCNCRMYY ISYSHDIDPE LATQIKPPEV LENQEKEDLL KKQEGAVDTF TLIHHELEIS 1620
TNPAQYAMIL DIVNNLLLHV EPKRKEHSEK KQRVRFQLEI SSNPEEQRSS ILHLQEAVRQ 1680
HVAQIRQLEK QMYSIMKSLQ DDSKNENLLD LNQKLQLQLN QEKANLQLES EELNILIRCF 1740
KDFQLQRANK MELRKQQEDV SVVRRTEFYF AQARWRLTEE DGQLGIAELE LQRFLYSKVN 1800
KSDDTAEHLL ELGWFTMNNL LPNAVYKAIL RPQSSCQSGR QLALRLFSKV RPPVGGISVK 1860
EHFEVNVVPL TIQLTHQFFH RMMGFFFPGR SVEDDEVGDE EDKSKLVTTG IPVVKPRQLI 1920
ATDDAVPLGP GKGVAQGLTR SSGVRRSFRK SPEHPVDDID KMKERAAMNN SFIYIKIPQV 1980
PLCVSYKGEK NSVDWGDLNL VLPCLEYHNN TWTWLDFAMA VKRDSRKALV AQVIKEKLRL 2040
KSATGSEVRG KLETKSDLNM QQQEEEEKAR LLIGLSVGDK NPGKKSIFGR RK 2092 
Gene Ontology
  
Interpro
 IPR019443; FMP27_C.
 IPR019441; FMP27_GFWDK_dom.
 IPR019439; FMP27_N. 
Pfam
 PF10351; Apt1
 PF10344; Fmp27
 PF10347; Fmp27_GFWDK 
SMART
  
PROSITE
  
PRINTS