CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029001
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ARF6 guanine nucleotide exchange factor IQArfGEF 
Protein Synonyms/Alias
 IQ motif and SEC7 domain-containing protein 2 
Gene Name
 Iqsec2 
Gene Synonyms/Alias
 IQArfGEF 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
409NPAYFEGKPASLDEGubiquitination[1]
913MKLDDFIKNLRGVDNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1479 AA 
Protein Sequence
MEAGSGPPGG PGSESPNRAV EYLLELNNII ESQQQLLETQ RRRIEELEGQ LDQLTQENRD 60
LREESQLHRG ELHRDPLGAR DSPGRESQYQ NLRETQFHHR ELRESQFHQA SRDVGYPNRD 120
GAYQNREAIY RDKEREASYQ LQDTTGYTAR ERDVAQCHLH HENPALGRER GGREAGPAHP 180
GREKEAGYSA AVGVGQRPPR ERGQLSRGAS RSSSPGAGGG HSTSTSTSPA TTLQRKSDGE 240
NSRTVSVEGD APGSDLSTAV DSPGSQPPYR LSQLPPTSSH MGGPPAGVGL PWAQRARLQP 300
ASVALRKQEE EEIKRSKALS DSYELSTDLQ DKKVEMLERK YGGSFLSRRA ARTIQTAFRQ 360
YRMNKNFERL RSSASESRMS RRIILSNMRM QFSFEEYEKA QNPAYFEGKP ASLDEGAMAG 420
ARSHRLERGL PYGGSCGGGI DGGGSSVTTS GEFSNDITEL EDSFSKQVKS LAESIDEALN 480
CHPSGPMSEE PGSAQLEKRE SKEQQEDSSA TSFSDLPLYL DDPVPPPSPE RLPSTEPPPQ 540
GRPEFWAPAP LPPVPPPMPP GTREDGSREE GTRRGPGCLE CRDFRLRAAH LPLLTIEPPS 600
DSSVDLSDRS DRGSVHRQLV YEADGCSPHG TLKHKGPPGR APIPHRHYPA PEGPAPAPPG 660
PLPPAPNSGT GPSGVAGGRR LGKCEAAGEN SDGGDNESLE SSSNSNETIN CSSGSSSRDS 720
LREPPATGLC KQTYQRETRH SWDSPAFNND VVQRRHYRIG LNLFNKKPEK GIQYLIERGF 780
LSDTPVGVAH FILERKGLSR QMIGEFLGNR QKQFNRDVLD CVVDEMDFSS MDLDDALRKF 840
QSHIRVQGEA QKVERLIEAF SQRYCVCNPA LVRQFRNPDT IFILAFAIIL LNTDMYSPSV 900
KAERKMKLDD FIKNLRGVDN GEDIPRDLLV GIYQRIQGRE LRTNDDHVSQ VQAVERMIVG 960
KKPVLSLPHR RLVCCCQLYE VPDPNRPQRL GLHQREVTKI FQKKKILVTY SFRQSFPLVE 1020
MHMQLFQNSY YQFGIKLLSA VPGGERKVLI IFNAPSLQDR LRFTSDLRES IAEVQEMEKY 1080
RVESELEKQK GMMRPNASQP GGAKDSVNGT LARSSLEDTY GAGDGLKRGA LSSSLRDLSD 1140
AGKRGRRNSV GSLDSTIEGS VISSPRPHQR MPPPPPPPPP EEYKSQRPVS NSSSFLGSLF 1200
GSKRGKGPFQ MPPPPTGQAS ASSSSASSTH HHHHHHHHGH SHGGLGVLPD GQSKLQALHA 1260
QYCQGPGPAP PPYLPPQQPP LPPPPQQPPP LPQLGSIPPP PASAPPVGPH RHFHAHGPVP 1320
GPQHYTLGRP GRAPRRGAGG HPQFAPHGRH PLHQPTSPLP LYSPAPQHPP AHKQGPKHFI 1380
FSHHPQMMPA AGAAGGPGSR PPGGSYSHPH HPQSPLSPHS PIPPHPSYPP LPPPSPHTPH 1440
SPLPPTSPHG PLHASGPPGT ANPPSANPKA KPSRISTVV 1479 
Gene Ontology
 GO:0030054; C:cell junction; IBA:RefGenome.
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0005086; F:ARF guanyl-nucleotide exchange factor activity; IBA:RefGenome.
 GO:0030036; P:actin cytoskeleton organization; IBA:RefGenome.
 GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR000904; Sec7.
 IPR023394; SEC7_alpha_orthog. 
Pfam
 PF01369; Sec7 
SMART
 SM00222; Sec7 
PROSITE
 PS50096; IQ
 PS50190; SEC7 
PRINTS