CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041126
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MCG11048, isoform CRA_c 
Protein Synonyms/Alias
 Very-long-chain enoyl-CoA reductase 
Gene Name
 Tecr 
Gene Synonyms/Alias
 mCG_11048 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
2******MKHYEVEIRubiquitination[1]
16RDAKTREKLCFLDKVacetylation[2]
16RDAKTREKLCFLDKVubiquitination[1]
22EKLCFLDKVEPQATIacetylation[3]
22EKLCFLDKVEPQATIubiquitination[1]
42LFTKTQGKSLKDEDVubiquitination[1]
45KTQGKSLKDEDVLQKacetylation[2, 3, 4, 5]
45KTQGKSLKDEDVLQKubiquitination[1]
52KDEDVLQKLPVGTTAubiquitination[1]
276GKHRSYLKEFRDYPPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 293 AA 
Protein Sequence
MKHYEVEIRD AKTREKLCFL DKVEPQATIS EIKTLFTKTQ GKSLKDEDVL QKLPVGTTAT 60
LYFRDLGAQI SWVTVFLTEY AGPLFIYLLF YFRVPFIYGR KYDFTSSRHT VVHLACMCHS 120
FHYIKRLLET LFVHRFSHGT MPLRNIFKNC TYYWGFAAWM AYYINHPLYT PPTYGVQQVK 180
LALAVFVICQ LGNFSIHMAL RDLRPAGSKT RKIPYPTKNP FTWLFLLVSC PNYTYEVGSW 240
IGFAILTQCV PVALFSLVGF TQMTIWAKGK HRSYLKEFRD YPPLRMPIIP FLL 293 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
 GO:0006629; P:lipid metabolic process; IEA:InterPro. 
Interpro
 IPR001104; 3-oxo-5_a-steroid_4-DH_C. 
Pfam
 PF02544; Steroid_dh 
SMART
  
PROSITE
 PS50244; S5A_REDUCTASE 
PRINTS