Tag | Content |
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CPLM ID | CPLM-021832 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein piccolo |
Protein Synonyms/Alias | Aczonin; Multidomain presynaptic cytomatrix protein |
Gene Name | Pclo |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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1338 | SDEKDLLKGLKKDSF | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking (By similarity). |
Sequence Annotation | DOMAIN 4442 4536 PDZ. DOMAIN 4653 4752 C2 1. DOMAIN 4968 5059 C2 2. ZN_FING 523 547 C4-type (Potential). ZN_FING 1010 1033 C4-type (Potential). REGION 372 491 12 X 10 AA tandem approximate repeats of MOD_RES 617 617 Phosphoserine (By similarity). MOD_RES 756 756 Phosphoserine (By similarity). MOD_RES 873 873 Phosphothreonine (By similarity). MOD_RES 1133 1133 Phosphothreonine (By similarity). MOD_RES 1352 1352 Phosphoserine (By similarity). MOD_RES 1353 1353 Phosphoserine (By similarity). MOD_RES 1412 1412 Phosphoserine (By similarity). MOD_RES 1451 1451 Phosphoserine (By similarity). MOD_RES 1456 1456 Phosphoserine (By similarity). MOD_RES 1469 1469 Phosphoserine (By similarity). MOD_RES 1587 1587 Phosphoserine (By similarity). MOD_RES 1597 1597 Phosphoserine (By similarity). MOD_RES 1772 1772 Phosphothreonine (By similarity). MOD_RES 1775 1775 Phosphoserine (By similarity). MOD_RES 1778 1778 Phosphoserine (By similarity). MOD_RES 1784 1784 Phosphoserine (By similarity). MOD_RES 1820 1820 Phosphoserine (By similarity). MOD_RES 1840 1840 Phosphotyrosine (By similarity). MOD_RES 1841 1841 Phosphoserine (By similarity). MOD_RES 3014 3014 Phosphothreonine (By similarity). MOD_RES 3374 3374 Phosphoserine (By similarity). MOD_RES 3392 3392 Phosphothreonine (By similarity). MOD_RES 3529 3529 Phosphothreonine (By similarity). MOD_RES 3561 3561 Phosphoserine (By similarity). MOD_RES 3626 3626 Phosphoserine (By similarity). MOD_RES 3632 3632 Phosphoserine (By similarity). MOD_RES 3779 3779 Phosphotyrosine (By similarity). MOD_RES 3781 3781 Phosphoserine (By similarity). MOD_RES 3912 3912 Phosphothreonine (By similarity). MOD_RES 3913 3913 Phosphothreonine (By similarity). MOD_RES 3954 3954 Phosphoserine (By similarity). MOD_RES 3970 3970 Phosphoserine (By similarity). MOD_RES 4304 4304 Phosphoserine (By similarity). MOD_RES 4308 4308 Phosphoserine (By similarity). MOD_RES 4311 4311 Phosphoserine (By similarity). MOD_RES 4343 4343 Phosphoserine (By similarity). CARBOHYD 2702 2702 O-linked (GlcNAc) (By similarity). CARBOHYD 2976 2976 O-linked (GlcNAc) (By similarity). |
Keyword | 3D-structure; Alternative splicing; Calcium; Calcium/phospholipid-binding; Cell junction; Complete proteome; Glycoprotein; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Synapse; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 5085 AA |
Protein Sequence | MGNEASLEGE GLPEGLAAAA GAGGSGSALH PGIPAGMEAD LSQLSEEERR QIAAVMSRAQ 60 GLPKGSVPPA AAESPSMHRK QELDSSQAPQ QPGKPPDPGR PTQPGLSKSR TTDTFRSEQK 120 LPGRSPSTIS LKESKSRTDF KEEYKSSMMP GFFSDVNPLS AVSSVVNKFN PFDLISDSEA 180 SQEETTKKQK VVQKEQGKSE GMAKPPLQQP SPKPIPKQQG QVKEVIQQDS SPKSVSSQQA 240 EKVKPQAPGT GKPSQQSPAQ TPAQQASPGK PVAQQPGSAK ATVQQPGPAK SPAQPAGTGK 300 SPAQPPAKTP GQQAGLEKTS SSQQPGPKSL AQTPGHGKFP LGPVKSPAQQ PGTAKHPAQQ 360 PGPQTAAKVP GPTKTPAQQS GPGKTPAQQP GPTKPSPQQP IPAKPQPQQP VATKTQPQQS 420 APAKPQPQQP APAKPQPQQP TPAKPQPQPP TPAKPQPQPP TATKPQPQPP TATKPHHQQP 480 GLAKPSAQQP TKSISQTVTG RPLQPPPTSA AQTPAQGLSK TICPLCNTTE LLLHIPEKAN 540 FNTCTECQST VCSLCGFNPN PHLTEIKEWL CLNCQMQRAL GGDLAAAIPS SPQPTPKAAT 600 APTATASKSP VPSQQASPKK EPPSKQDSPK ALESKKPPEP KKPPEPKKPP EPKKPPPLVK 660 QPTLHGPTPA TAPQLPVAEA LPEPAPPKEP SGPLPEQAKA PVGDVEPKQP KMTETRADIQ 720 SSSTTKPDIL SSQVQSQAQV KTASPLKTDS AKPSQSFPPT GEKTTPLDSK AMPRPASDSK 780 IISQPGPGSE SKDPKHIDPI QKKDEPKKAQ PKGSPKPETK PVPKGSPTPS GTRPTAGQAA 840 PPSQQPPKPQ EQSRRFSLNL GGITDAPKSQ PTTPQETVTG KLFGFGASIF SQASNLISTA 900 GQQGPHPQTG PAAPSKQAPT PSQSPAAQGP AKSTGQLPPA PAKATAVKKE AKAAAAENLE 960 SKPEQAPTAK KTEKDKKPPP AKVGKPPPSE PEKAVPAHKP DKTTKPKPAC PLCRTELNLG 1020 SQEPPNFNTC TECKNQVCNL CGFNPTPHLT EIQEWLCLNC QTQRAISGQL GDMGKMPPAP 1080 SGPKASPMPA PAEPSSQKTP TGTQVKGKKK EAEGKTEAEK PVPEKETASI EKTPPMVTTD 1140 QKLEESEGKK SKVSALPEKK PSEEEKAISA DKKERKPPAE EKPPLEEKKP IPVDKKLPPE 1200 AKPLSSEGEE KHEILKAHVQ IPEEEPTGKV AAKAGEEEQQ PDSRPEALPG ATPLTLPKAG 1260 EKERAVAQPQ AEGSSKDGQG ERSKEKTEKE EDKSDTSSSQ QPKSPQGLSD TGYSSDGISG 1320 SLGEIPSLIP SDEKDLLKGL KKDSFSQESS PSSPSDLAKL ESTVLSILEA QASTLVGEKA 1380 EKKTQPQKIS PEKPQDQQKT QTASETLDIT ISEEEIKESQ EKKVSPKKDS EQGFPSRKEH 1440 KEKPELVDDL SPRRASYDSV EDSSESENSP VVRRKRRTSI GSSSSDEYKQ EDSQGSGEEE 1500 DFIRKQIIEM SADEDASGSE DEEFIRSQLK EISGVGESQK REEAKGKGKG VAGKHRRLTR 1560 KSSTSFDDDA GRRHSWHDED DETFDESPEL KFRETKSQES EELVVAGGGG LRRFKTIELN 1620 STIADKYSSE SSQKKTILYF DEEPELEMES LTDSPEDRSR GEGSSSLHAS SFTPGTSPTS 1680 VSSLDEDSDS SPSHKKGESK QQRKARHRSH GPLLPTIEDS SEEEELREEE ELLKEQEKQR 1740 ELEQQQRKSS SKKSKKDKDE LRAQRRRERP KTPPSNLSPI EDASPTEELR QAAEMEELHR 1800 SSCSEYSPSI ESDPEGFEIS PEKIIEVQKV YKLPAAVSLY SPTDEQSVMQ KEGVQKALKS 1860 AEEMYEEMMQ KPHKYKAFPA ANERDEVFEK EPLYGGMLIE DYIYESLVED TYNGSVDGSL 1920 LTRQEEQNGF MQQRGREQKV RLQEQIYDDP MQKISDLQKE FYELESLHSV VPQEDIVSSS 1980 YIIPESHEIV DLGSMVMSTS EEKKLLDADS AYEELMRRQQ VQVTDGSSPV QTTIGDDMAE 2040 STLDFDRVQD ASLTSSILSG ASLTDSTSSA TLSIPDVKIT QQFSAEELED EYVTDYTREI 2100 QDIIAHESLI LTYSEPSESA TSVPPSDTPS LTSSISSVCT TDSSSPVTTL DSLTTVYTEP 2160 ADVMTKFKDS EEISSTYFPG SIIDYPEDIS VSLDRTIMPE SRTNEDRIVL SFSGMAPSVV 2220 ESVGTKPERP QADTISTDLP ISEKDLIKGK KETGDGIILE VLDAYKDKRE ESEAELTKIS 2280 LPEPGLAQAP SSVTAPQIKE QHVSPHSVSG KISGQEKPTY RLPSGSLPVS THPSKSRPFF 2340 RSSSLDISAQ PPPPPPPPPP SPSTSSPPPT PPLPPATSPK PPTYPKKKLA VAATVTSTTI 2400 VTTHVDALTM VEAAAARRSN GLPATKMCAI APPPVPPKPS QIPTGLVFTH RPEAIKPPIA 2460 PKPAVPQIPV TTQKPTDTCP KPTGLSLTST MSLNLVTSAD YNVPSPTSPL SPHSNKSSPR 2520 YSKSLMDTYV VITLPSEPGT PTDSSAAQAI TSWPLGSPPK DLVSLETVFS VVPPMTSTEI 2580 PSASQPTLYT SGALGTFSVT PAVTASLFQT VPTSLTQFLP AEASKPEVSA VSSAVPSVAP 2640 RSVSIPIPPE PLALDRHQYK ENGKLPLIGD AIDLRTIPKS EVKVTEKCMD LSASAMDVKR 2700 QTTANEVYRR QISAVQPSII NLSAASSLGT PVTMDSKTVA VVTCTDTTIY TTGTESQVGI 2760 EHAVTSPLQL TTSKHTELPY RKPSSQAFPT IRDEAPINLS LGPSAQAVTL AVTKPVTVPP 2820 VGVTNGWTDS TLSQGVADGE VVDLSTSKSH RTVVTMDEST SNVVTKIIED DEKPVDLTAG 2880 RRAVCCDMVY TLPFGRSCTA QQPATTLPED RFGYRDDHYQ YDRSGPYGYR GIGGMKPSMS 2940 DTNLPEAGHF FYKSKNAFDY SGGTGAAVDL TSGRVSTGEV MDYSSKTTGP YPETRQVISG 3000 VGISTPQYST ARLTPPPGPQ YGVGSVLRSS NGVVYSSVAT PIPSTFAITT QPGSIFSTTV 3060 RDLSGIPTTD AMTSLSALHQ SQPMPRSYFI TTGASETDIA VTGIDINASL QTITMETLPA 3120 ETMDSVPTLT TASEVFSEVV GEESTLLIVP DEDKQQQQLD LERELLELEK IKQQRFAEEL 3180 EWERQEIQRF REQEKIMVQK KLEELQSMKQ HLLYQQEEER QAQFMMRQET LAQQQLQLEQ 3240 IQQLQQQLHQ QLEEQKLRQI YQYNYDPSGT SSPQTTTEQA ILEGQYAATE GSQFWATEDA 3300 TTTASTVVAI EIPQSQGWYT VQSDGVTQYI APPGILSTVS EIPLTDVVVK EEKQPKKRSS 3360 GAKVRGQYDE MGESVADDPR NLKKIVDSGV QTDDEETADR SYASRRRRTK KSVDTSVQTD 3420 DEDQDEWDMP SRSRRKARTG KYGDSTAEGD KTKPLSKVSS VAVQTVAEIS VQTEPVGTIR 3480 TPSIRARVDA KVEIIKHISA PEKTYKGGSL GCQTETDSDT QSPPYLGATS PPKDKKRPTP 3540 LEIGYSSSHL RADPTVQLAP SPPKSPKVLY SPISPLSPGN ALEPAFVPYE KPLPDDISPQ 3600 KVLHPDMAKV PPASPKTAKM MQRSMSDPKP LSPTADESSR APFQYSEGFT TKGSQTMTAS 3660 GTQKKVKRTL PNPPPEEVST GTQSTYSTMG TASRRRMCRT NTMARAKILQ DIDRELDLVE 3720 RESAKLRKKQ AELDEEEKEI DAKLRYLEMG INRRKEALLK EREKRERAYL QGVAEDRDYM 3780 SDSEVSSTRP SRVESQHGVE RPRTAPQTEF SQFIPPQTQT EAQLVPPTSP YTQYQYSSPA 3840 LPTQAPTPYT QQSHFQQQTL YHQQVSPYQT QPTFQAVATM SFTPQAQPTP TPQPSYQLPS 3900 QMMVIQQKPR QTTLYLEPKI TSNYEVIRNQ PLMIAPVSTD NTYAVSHLGS KYNSLDLRIG 3960 LEERSSMAGS PISSISADSF YADIDHHTSR NYVLIDDIGD ITKGTAALST VFSLHEKDLS 4020 KTDRLLRTTE TRRSQEVTDF LAPLQTSSRL HSYVKADEDP MEDPYELKLL KHQIKQEFRR 4080 GTESLDHLAG LSHYYHADTS YRHFPKSEKY SISRLTLEKQ AAKQLPAAIL YQKQSKHKKS 4140 LIDPKMSKFS PIQESRDLEP DYPTYMSSGT SSIGGISSRA RLLQDDITFG LRKNITDQQK 4200 FMGSSLGSGL GTLGNTIRSA LQDEADKPYS SGSRSRPSSR PSSVYGLDLS IKRDSSSSSL 4260 RLKAQEAEAL DVSFGHSSSS ARTKPTSLPI SQSRGRIPIV AQSSEEESPL SPVGQPMGMA 4320 RAAAGPLPPI SADTRDQFGS SHSLPEVQQH MREESRTRGY DRDIAFIMDD FQHAMSDSEA 4380 YHLRREETDW FDKPRESRLE NGHGLDRKLP ERLVHSRPLS QHQEQILQMN GKTIHYIFPH 4440 ARVKITRDFK DHTGSGNGLG IRIVGGKEIP GHSGEIGAYI AKILPGESAE HTGPLMEGMQ 4500 VLEWNGVPLT SKTYEEVQSI INQQSGEAEI CVRLDLNMLS DSENPQHLEL HEPPKVDKAK 4560 SPGVDPKQLA AELQKVSLQQ SPLVMSSVVE KGSHAHSGPT SAGSSSVPSP GQPGSPSVSK 4620 KKHSSTKPTD GPKAASHPIT GEIQLQINYD LGNLIIHILQ ARNLVPRDNN GYSDPFVKVY 4680 LLPGRGQVMV VQNASAEYKR RTKYVQKSLN PEWNQTVIYK SISMEQLMKK TLEVTVWDYD 4740 RFSSNDFLGE VLIDLSSTSH LDNTPRWYPL KEQTESIDHG KSHSSQNSQQ SPKPSVIKSR 4800 SHGIFPDPSK DMQVPTIEKS HSSPGSSKSS SEGHLRSHGP SRSQSKTSVA QTHLEDAGVA 4860 IAAAEAAVQQ LRIQPTKPTN HRPAESSVST GSSGSSVGSG YSVDSEGSSC VAGEPNLLPI 4920 PRIGKMGQNG QDPVKQPGMG ATDTEGKTQV MGEIKLALKK EMKTDGEQLI VEILQCRNIT 4980 YKFKSPDHLP DLYVKLYVIN ISTQKKVIKK KTRVCRHDRE PSFNETFRFS LSPAGHSLQI 5040 LLFSNGGKFM KKTLIGEACI WLDKVDLRKR IVNWHKLLVS PTQTH 5085 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0045202; C:synapse; IDA:UniProtKB. GO:0005509; F:calcium ion binding; IDA:UniProtKB. GO:0005544; F:calcium-dependent phospholipid binding; IDA:UniProtKB. GO:0005522; F:profilin binding; ISS:UniProtKB. GO:0007010; P:cytoskeleton organization; ISS:UniProtKB. GO:0016080; P:synaptic vesicle targeting; NAS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |