| Tag | Content |
|---|
| CPLM ID | CPLM-006321 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Exportin-T |
Protein Synonyms/Alias | Exportin(tRNA); Karyopherin-beta; tRNA exportin |
Gene Name | LOS1 |
Gene Synonyms/Alias | YKL205W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 280 | CILAIISKKMKPMDK | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Preferentially interacts with tRNAs with mature 5'- and 3'-termini and does not distinguish between intron-containing and spliced tRNAs. In the nucleus binds to tRNA and to the Ran-GTPases GSP1 or GSP2 in their active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of the tRNA from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease. |
Sequence Annotation | |
Keyword | Complete proteome; Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport; tRNA processing; tRNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1100 AA |
Protein Sequence | MLERIQQLVN AVNDPRSDVA TKRQAIELLN GIKSSENALE IFISLVINEN SNDLLKFYGL 60
STLIELMTEG VNANPNGLNL VKFEITKWLK FQVLGNKQTK LPDFLMNKIS EVLTTLFMLM 120
YSDCNGNQWN SFFDDLMSLF QVDSAISNTS PSTDGNILLG LEFFNKLCLM INSEIADQSF 180
IRSKESQLKN NNIKDWMRDN DIMKLSNVWF QCLKLDEQIV SQCPGLINST LDCIGSFISW 240
IDINLIIDAN NYYLQLIYKF LNLKETKISC YNCILAIISK KMKPMDKLAF LNMINLTNEL 300
TYYHQAISMN PQIITFDNLE VWESLTKLIT SFGIEFTIII EQVNDDQKLD TLYKQSVISN 360
VDSILLEKII PILLEFMNNE FDSITAKTFP FWSNYLAFLK KYKASSPNFV PLHKDFLDNF 420
QQICFKRMKF SDDEVTQDDF EEFNETVRFK LKNFQEIIVV IDPSLFLNNI SQEISANLMN 480
CKNESWQIFE LTIYQIFNLS ECTKNNYFGL NKNEIMTSQP SLTLVRFLNE LLMMKDFLLA 540
IDNEQIQILF MELIVKNYNF IFSTSANTAN ATDDDEKYLL ILNIFMSSFA MFNKRENVRL 600
RSWYLFTRFL KLTRINLKKI LFANKNLVNE ITNKISPLLH IKVTSINAQG TDDNDTIFDN 660
QLYIFEGIGF IITLNNSSQE LTAATANTPI DYDILDQILT PLFTQLEGCI TQGASPVVIL 720
ECHHILMAIG TLARGLHIGL VPENQVNNMV VNKKLINDSL IHKFSNIAEV ILVTFSFFNK 780
FENIRDASRF TFARLIPILS NKILPFINKL IELILSSTDL KSWEMIDFLG FLSQLIHMFH 840
TDTDCYQLFN QLLTPLINKV HSIIEEIDEQ HDQQSSSNKP IDTAVTATSV NKNIVVTDSY 900
RDKILLKKAY CTFLQSFTNN SVTSILLSDI NRAILPVILN DLVTYTPQEI QETSMMKVSL 960
NVLCNFIKCF GNGTCLDNDD INKDPNLKID GLNEYFIMKC VPIIFEIPFN PIYKFNIKEG 1020
NFKTMAYDLA RLLRELFIVS SNPTTNENEC VKYLTQIYLP QIQLPQELTI QLVNMLTTMG 1080
QKQFEKWFVD NFISVLKQGQ 1100 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |