| Tag | Content |
|---|
| CPLM ID | CPLM-011357 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Multiple RNA-binding domain-containing protein 1 |
Protein Synonyms/Alias | |
Gene Name | MRD1 |
Gene Synonyms/Alias | YPR112C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 768 | KSGKIIVKNLPFEAT | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Involved in pre-rRNA processing. Required for maintaining steady-state levels of 40S ribosomal subunit. Required for the initial processing of pre-rRNA at the A0 to A2 sites, leading to the processing of the 23S pre-rRNA intermediate to the 18S rRNA. |
Sequence Annotation | DOMAIN 2 94 RRM 1.
DOMAIN 345 423 RRM 2.
DOMAIN 532 604 RRM 3.
DOMAIN 663 746 RRM 4.
DOMAIN 763 840 RRM 5.
MOD_RES 220 220 Phosphoserine.
MOD_RES 264 264 Phosphoserine. |
Keyword | Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; rRNA processing. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 887 AA |
Protein Sequence | MSRIIVKGLP VYLTDDNLRE HFTKRLRQKH SHQAVNGSGP DLITDVKILR DRNGESRRFG 60
FIGYRNEEDA FDAVEYFNGS FINTSKIEVS MAKSFADPRV PQPMKEKRRE ALKRFREKEE 120
KLLQEENRKK KKVDENKHSN IDDEIRKNKQ LQEFMETMKP SSQVTSWEKV GIDKSIEDEK 180
LKREEEDSSV QGNSLLAHAL ALKEENNKDE APNLVIENES DDEYSALNRN RDEDQEDAGE 240
EEKMISISNL KDTDIGLVND DANSDEKENE KRRNLAQDEK VSDLDWFKQR RVRIKESEAE 300
TREKSSSYAT EQNESLDTKK EEQPERAVPQ KTDEELAIEK INQTGRLFLR NILYTSKEED 360
FRKLFSPFGE LEEVHVALDT RTGQSKGFAY VLFKDSKNAV NAYVELDKQI FQGRLLHILP 420
GEEKKSHRLD EFDLKNMPLK KQKELKRKAA ASRQTFSWNS LYMNQDAVLG SVAAKLGLEK 480
SQLIDAENSS SAVKQALAEA HVIGDVRKYF ESKGVDLTKF SQLKSTNQRD DKVILVKNFP 540
FGTTREELGE MFLPYGKLER LLMPPAGTIA IVQFRDTTSA RAAFTKLSYK RFKDGIIYLE 600
RGPKDCFTKP AEADDLINNT SAKEEENPVE VKPSSNDLME ANKDVTEGSS NAHDEDVIDG 660
PTVSIFIKNL NFSTTNQNLT DRFKVFTGFV VAQVKTKPDP KHQGKTLSMG FGFVEFRTKE 720
QANAVIAAMD GTVIDGHKIQ LKLSHRQASQ SGNTKTKSNK KSGKIIVKNL PFEATRKDVF 780
ELFNSFGQLK SVRVPKKFDK SARGFAFVEF LLPKEAENAM DQLHGVHLLG RRLVMQYAEE 840
DAVDAEEEIA RMTKKVRKQV ATNEMAALRN GGGRKKLDVD DEENEGF 887 |
Gene Ontology | GO:0030686; C:90S preribosome; IDA:SGD. GO:0005730; C:nucleolus; IDA:SGD. GO:0000166; F:nucleotide binding; IEA:InterPro. GO:0042134; F:rRNA primary transcript binding; IDA:SGD. GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. GO:0034462; P:small-subunit processome assembly; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |