| Tag | Content |
|---|
| CPLM ID | CPLM-006731 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phosphatidylinositol N-acetylglucosaminyltransferase subunit A |
Protein Synonyms/Alias | GlcNAc-PI synthesis protein; Phosphatidylinositol-glycan biosynthesis class A protein; PIG-A |
Gene Name | PIGA |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 293 | LLGALEHKDVRNVLV | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis. |
Sequence Annotation | MOD_RES 21 21 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Disease mutation; Endoplasmic reticulum; Glycosyltransferase; GPI-anchor biosynthesis; Membrane; Phosphoprotein; Reference proteome; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 484 AA |
Protein Sequence | MACRGGAGNG HRASATLSRV SPGSLYTCRT RTHNICMVSD FFYPNMGGVE SHIYQLSQCL 60
IERGHKVIIV THAYGNRKGI RYLTSGLKVY YLPLKVMYNQ STATTLFHSL PLLRYIFVRE 120
RVTIIHSHSS FSAMAHDALF HAKTMGLQTV FTDHSLFGFA DVSSVLTNKL LTVSLCDTNH 180
IICVSYTSKE NTVLRAALNP EIVSVIPNAV DPTDFTPDPF RRHDSITIVV VSRLVYRKGI 240
DLLSGIIPEL CQKYPDLNFI IGGEGPKRII LEEVRERYQL HDRVRLLGAL EHKDVRNVLV 300
QGHIFLNTSL TEAFCMAIVE AASCGLQVVS TRVGGIPEVL PENLIILCEP SVKSLCEGLE 360
KAIFQLKSGT LPAPENIHNI VKTFYTWRNV AERTEKVYDR VSVEAVLPMD KRLDRLISHC 420
GPVTGYIFAL LAVFNFLFLI FLRWMTPDSI IDVAIDATGP RGAWTNNYSH SKRGGENNEI 480
SETR 484 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IDA:HGNC. GO:0000506; C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; IDA:HGNC. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0017176; F:phosphatidylinositol N-acetylglucosaminyltransferase activity; TAS:HGNC. GO:0006501; P:C-terminal protein lipidation; TAS:Reactome. GO:0009893; P:positive regulation of metabolic process; TAS:HGNC. GO:0016254; P:preassembly of GPI anchor in ER membrane; TAS:Reactome. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |