CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040289
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Histone-lysine N-methyltransferase MLL4 
Protein Synonyms/Alias
  
Gene Name
 Kmt2b 
Gene Synonyms/Alias
 Wbp7 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
990HTDLLDGKEIVTPDGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Methyltransferase; Nucleus; Reference proteome; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2014 AA 
Protein Sequence
XSLPRFVPVV TSPVKVEVPP HGAPALSEGQ QLQLQQPPQA LQTQLLPQAL PPQQPQAQPP 60
PSPQHTPPLE KARVASLGSL PLSGVEEKMF SLLKRAKVQL FKIDQQQQQK VAASMPLSPA 120
VQTEEAVGTV KQTPDRGCVR SEDESMEAKR DRASGPESPL QGPRIKHVCR HAAVALGQAR 180
AMVPEDVPRL SALPLRDRQD LATEDTSSAS ETESVPSRSQ REKVESAGPG GDSEPTGSTG 240
ALAHTPRRSL PSHHGKKMRM ARCGHCRGCL RVQDCGSCVN CLDKPKFGGP NTKKQCCVYR 300
KCDKIEARKM ERLAKKGRTI VKTLLPWDSD ESPEASPGPP GPRRGAGAGG SREEVGATPG 360
PEEQDSLLLQ RKSARRCVKQ RPSYDVFEDS DDSEPGGPPA PRRRTPREHE LPVLEPEEQS 420
RPRKPTLQPV LQLKARRRLD KDALAPGPFA SFPNGWTGKQ KSPDGVHRVR VDFKEDCDLE 480
NVWLMGGLSV LTSVPGGPPM VCLLCASKGL HELVFCQVCC DPFHPFCLEE AERPSPQHRD 540
TWCCRRCKFC HVCGRKGRGS KHLLECERCR HAYHPACLGP SYPTRATRRR RHWICSACVR 600
CKSCGATPGK NWDVEWSGDY SLCPRCTELY EKGNYCPICT RCYEDNDYES KMMQCAQCDH 660
WVHAKCEGLS DEDYEILSGL PDSVLYTCGP CAGATQPRWR EALSGALQGG LRQVLQGLLS 720
SKVAGPLLLC TQCGQDGKQL HPGPCDLQAV GKRFEEGLYK SVHSFMEDVV AILMRHSEEG 780
ETPERRAGSQ MKGLLLKLLE SAFCWFDAHD PKYWRRSTRL PNGVLPNAVL PPSLDHVYAQ 840
WRQQESETPE SGQPPGDPSA AFQSKDPAAF SHLDDPRQCA LCLKYGDADS KEAGRLLYIG 900
QNEWTHVNCA IWSAEVFEEN DGSLKNVHAA VARGRQMRCE LCLKPGATVG CCLSSCLSNF 960
HFMCARASYC IFQDDKKVFC QKHTDLLDGK EIVTPDGFDV LRRVYVDFEG INFKRKFLTG 1020
LEPDVINVLI GSIRINSLGT LSDLSDCEGR LFPIGYQCSR LYWSTVDARR RCWYRCRILE 1080
YRPWGPREEP VHLEAAEENQ TIVHSPTPSS EPPNHDDLPD TDSLIPGDPV HHSPIQNLDP 1140
PLRTDSSNGP PPTPRSFSGA RIKVPNYSPS RRPLGGVSFG PLPSPGSPSS LTHHIPTVGD 1200
SDFPAPPRRS RRPSPLATRP PPSRRTSSPL RTSPQLRVPL STSVTALTPT SGELAPPDLA 1260
PSPLPPSEDL GPDFEDMEVV SGLSAADLDF AASLLGTEPF QEEIVAAGAV GSSQGGPGDS 1320
SEEEASPTTH YVHFPVTVVS GPALAPSSLA GAPRIEQLDG VDDGTDSEAE AVQQPRGQGT 1380
PPSGPGVGRG GVLGAAGDRA QPPEDLPSEI VDFVLKNLGG PGEGAAGPRE DSLPSAPPLA 1440
NGSQPPQSLS TSPADPTRTF AWLPGAPGVR VLSLGPAPEP PKPATSKIIL VNKLGQVFVK 1500
MAGEGEPVAP PVKQPPLPPI IPPTAPTSWT LPPGPLLSVL PVVGVGVVRP APPPPPPPLT 1560
LVFSSGPPSP PRQAIRVKRV STFSGRSPPV PPPNKTPRLD EDGESLEDAH HVPGISGSGF 1620
SRVRMKTPTV RGVLDLNNPG EQPEEESPGR PQDRCPLLPL AEAPSQALDG SSDLLFESQW 1680
HHYSAGEASS SEEEPPSPED KENQVPKRVG PHLRFEISSD DGFSVEAESL EVAWRTLIEK 1740
VQEARGHARL RHLSFSGMSG ARLLGIHHDA VIFLAEQLPG AQRCQHYKFR YHQQGEGQEE 1800
PPLNPHGAAR AEVYLRKCTF DMFNFLASQH RVLPEGATCD EEEDEVQLRS TRRATSLELP 1860
MAMRFRHLKK TSKEAVGVYR SAIHGRGLFC KRNIDAGEMV IEYSGIVIRS VLTDKREKFY 1920
DGKGIGCYMF RMDDFDVVDA TMHGNAARFI NHSCEPNCFS RVIHVEGQKH IVIFALRRIL 1980
RGEELTYDYK FPIEDASNKL PCNCGAKRCR RFLN 2014 
Gene Ontology
 GO:0035097; C:histone methyltransferase complex; ISO:MGI.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0042800; F:histone methyltransferase activity (H3-K4 specific); ISO:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0016458; P:gene silencing; IMP:MGI.
 GO:0080182; P:histone H3-K4 trimethylation; IMP:MGI.
 GO:0009994; P:oocyte differentiation; IMP:MGI.
 GO:0001541; P:ovarian follicle development; IMP:MGI.
 GO:0030728; P:ovulation; IMP:MGI.
 GO:0051569; P:regulation of histone H3-K4 methylation; IMP:MGI. 
Interpro
 IPR003889; FYrich_C.
 IPR003888; FYrich_N.
 IPR015722; Histone-lysine_MeTfrase.
 IPR003616; Post-SET_dom.
 IPR001214; SET_dom.
 IPR002857; Znf_CXXC.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF05965; FYRC
 PF05964; FYRN
 PF00628; PHD
 PF00856; SET
 PF02008; zf-CXXC 
SMART
 SM00542; FYRC
 SM00541; FYRN
 SM00249; PHD
 SM00508; PostSET
 SM00317; SET 
PROSITE
 PS51543; FYRC
 PS51542; FYRN
 PS50868; POST_SET
 PS50280; SET
 PS51058; ZF_CXXC
 PS50016; ZF_PHD_2 
PRINTS