| Tag | Content |
|---|
| CPLM ID | CPLM-004254 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Glycylpeptide N-tetradecanoyltransferase |
Protein Synonyms/Alias | Cell division control protein 72; Myristoyl-CoA:protein N-myristoyltransferase; NMT; Peptide N-myristoyltransferase |
Gene Name | NMT1 |
Gene Synonyms/Alias | CDC72; YLR195C; L8167.14 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 188 | RLTPVLIKEITRRVN | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. Substrate specificity requires an N- terminal glycine in the nascent polypeptide substrates. Uncharged amino acids are preferred at position 2 while neutral residues are favored at positions 3 and 4. Ser is present at position 5 in almost all known N-myristoyl proteins and Lys is commonly encountered at postion 6. |
Sequence Annotation | REGION 38 41 Myristoyl CoA-binding.
REGION 168 204 Myristoyl CoA-binding.
ACT_SITE 455 455 Proton acceptor; via carboxylate. |
Keyword | 3D-structure; Acyltransferase; Complete proteome; Cytoplasm; Direct protein sequencing; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 455 AA |
Protein Sequence | MSEEDKAKKL ENLLKLLQLN NDDTSKFTQE QKKAMKDHKF WRTQPVKDFD EKVVEEGPID 60
KPKTPEDISD KPLPLLSSFE WCSIDVDNKK QLEDVFVLLN ENYVEDRDAG FRFNYTKEFF 120
NWALKSPGWK KDWHIGVRVK ETQKLVAFIS AIPVTLGVRG KQVPSVEINF LCVHKQLRSK 180
RLTPVLIKEI TRRVNKCDIW HALYTAGIVL PAPVSTCRYT HRPLNWKKLY EVDFTGLPDG 240
HTEEDMIAEN ALPAKTKTAG LRKLKKEDID QVFELFKRYQ SRFELIQIFT KEEFEHNFIG 300
EESLPLDKQV IFSYVVEQPD GKITDFFSFY SLPFTILNNT KYKDLGIGYL YYYATDADFQ 360
FKDRFDPKAT KALKTRLCEL IYDACILAKN ANMDVFNALT SQDNTLFLDD LKFGPGDGFL 420
NFYLFNYRAK PITGGLNPDN SNDIKRRSNV GVVML 455 |
Gene Ontology | GO:0005829; C:cytosol; IDA:SGD. GO:0004379; F:glycylpeptide N-tetradecanoyltransferase activity; TAS:SGD. GO:0018008; P:N-terminal peptidyl-glycine N-myristoylation; TAS:SGD. GO:0001302; P:replicative cell aging; IMP:SGD. |
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Pfam | |
SMART | |
PROSITE | |
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