| Tag | Content |
|---|
| CPLM ID | CPLM-017441 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | SH2 domain-containing protein 3C |
Protein Synonyms/Alias | Novel SH2-containing protein 3; SH2 domain-containing Eph receptor-binding protein 1; SHEP1 |
Gene Name | SH2D3C |
Gene Synonyms/Alias | NSP3; UNQ272/PRO309/PRO34088 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 340 | GLGQGSSKPASPVSP | ubiquitination | [1] | | 577 | LEVGLLRKVKELLAE | ubiquitination | [1] | | 579 | VGLLRKVKELLAEVD | ubiquitination | [1] | | 609 | ARILGVTKEMQTLMG | ubiquitination | [1] | | 720 | EGAILYEKKLKPFLK | ubiquitination | [1] | | 721 | GAILYEKKLKPFLKS | ubiquitination | [1] | | 850 | VLTALSHKLEPAVRS | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity). |
Sequence Annotation | DOMAIN 220 319 SH2.
DOMAIN 586 854 Ras-GEF.
MOD_RES 278 278 Phosphotyrosine (By similarity).
MOD_RES 283 283 Phosphotyrosine (By similarity).
MOD_RES 793 793 Phosphotyrosine (By similarity). |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Polymorphism; Reference proteome; SH2 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 860 AA |
Protein Sequence | MTEGTKKTSK KFKFFKFKGF GSLSNLPRSF TLRRSSASIS RQSHLEPDTF EATQDDMVTV 60
PKSPPAYARS SDMYSHMGTM PRPSIKKAQN SQAARQAQEA GPKPNLVPGG VPDPPGLEAA 120
KEVMVKATGP LEDTPAMEPN PSAVEVDPIR KPEVPTGDVE EERPPRDVHS ERAAGEPEAG 180
SDYVKFSKEK YILDSSPEKL HKELEEELKL SSTDLRSHAW YHGRIPREVS ETLVQRNGDF 240
LIRDSLTSLG DYVLTCRWRN QALHFKINKV VVKAGESYTH IQYLFEQESF DHVPALVRYH 300
VGSRKAVSEQ SGAIIYCPVN RTFPLRYLEA SYGLGQGSSK PASPVSPSGP KGSHMKRRSV 360
TMTDGLTADK VTRSDGCPTS TSLPRPRDSI RSCALSMDQI PDLHSPMSPI SESPSSPAYS 420
TVTRVHAAPA APSATALPAS PVARRSSEPQ LCPGSAPKTH GESDKGPHTS PSHTLGKASP 480
SPSLSSYSDP DSGHYCQLQP PVRGSREWAA TETSSQQARS YGERLKELSE NGAPEGDWGK 540
TFTVPIVEVT SSFNPATFQS LLIPRDNRPL EVGLLRKVKE LLAEVDARTL ARHVTKVDCL 600
VARILGVTKE MQTLMGVRWG MELLTLPHGR QLRLDLLERF HTMSIMLAVD ILGCTGSAEE 660
RAALLHKTIQ LAAELRGTMG NMFSFAAVMG ALDMAQISRL EQTWVTLRQR HTEGAILYEK 720
KLKPFLKSLN EGKEGPPLSN TTFPHVLPLI TLLECDSAPP EGPEPWGSTE HGVEVVLAHL 780
EAARTVAHHG GLYHTNAEVK LQGFQARPEL LEVFSTEFQM RLLWGSQGAS SSQARRYEKF 840
DKVLTALSHK LEPAVRSSEL 860 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0016020; C:membrane; IEA:UniProtKB-SubCell. GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro. GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc. GO:0007254; P:JNK cascade; TAS:ProtInc. GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |