CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010577
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Isochorismatase domain-containing protein 2A, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Isoc2a 
Gene Synonyms/Alias
 Isoc2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
26FLCDLQEKFRPSIAYacetylation[1]
26FLCDLQEKFRPSIAYsuccinylation[1]
93SMVPALQKELDGRSQacetylation[1, 2, 3, 4]
93SMVPALQKELDGRSQsuccinylation[1]
178DASHPQFKEIQKIIKacetylation[1, 2, 3, 4, 5, 6, 7, 8]
178DASHPQFKEIQKIIKsuccinylation[1]
182PQFKEIQKIIKEPVPacetylation[2, 3, 4, 9]
185KEIQKIIKEPVPDSGacetylation[3]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647]
 [6] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [7] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [8] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599]
 [9] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
 J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Cytoplasm; Mitochondrion; Nucleus; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 206 AA 
Protein Sequence
MAAARASLGR ILPESSILFL CDLQEKFRPS IAYFPQIVSV AARMLKVARL LDVPILLTEQ 60
YPEGLGPTVP ELGAQGIRPV SKTCFSMVPA LQKELDGRSQ LQSVLLCGIE TQACILNTAL 120
DLLHRGLQVH VVVDACSSRS QVDRLVALAR MRQSGAFLAT SESLILQLVR DASHPQFKEI 180
QKIIKEPVPD SGLLSLFQGQ SPLTSC 206 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003824; F:catalytic activity; IEA:InterPro. 
Interpro
 IPR000868; Isochorismatase-like. 
Pfam
 PF00857; Isochorismatase 
SMART
  
PROSITE
  
PRINTS