| Tag | Content |
|---|
| CPLM ID | CPLM-000732 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Carbonic anhydrase 12 |
Protein Synonyms/Alias | Carbonate dehydratase XII; Carbonic anhydrase XII; CA-XII; Tumor antigen HOM-RCC-3.1.3 |
Gene Name | CA12 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 336 | VIYKPATKMETEAHA | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Reversible hydration of carbon dioxide. |
Sequence Annotation | REGION 226 227 Substrate binding (By similarity).
ACT_SITE 94 94 Proton acceptor (By similarity).
ACT_SITE 154 154 By similarity.
METAL 119 119 Zinc; catalytic.
METAL 121 121 Zinc; catalytic.
METAL 145 145 Zinc; catalytic.
CARBOHYD 28 28 N-linked (GlcNAc...) (Potential).
CARBOHYD 80 80 N-linked (GlcNAc...) (Potential).
CARBOHYD 162 162 N-linked (GlcNAc...) (Potential).
DISULFID 50 230 |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Lyase; Membrane; Metal-binding; Reference proteome; Signal; Transmembrane; Transmembrane helix; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 354 AA |
Protein Sequence | MPRRSLHAAA VLLLVILKEQ PSSPAPVNGS KWTYFGPDGE NSWSKKYPSC GGLLQSPIDL 60
HSDILQYDAS LTPLEFQGYN LSANKQFLLT NNGHSVKLNL PSDMHIQGLQ SRYSATQLHL 120
HWGNPNDPHG SEHTVSGQHF AAELHIVHYN SDLYPDASTA SNKSEGLAVL AVLIEMGSFN 180
PSYDKIFSHL QHVKYKGQEA FVPGFNIEEL LPERTAEYYR YRGSLTTPPC NPTVLWTVFR 240
NPVQISQEQL LALETALYCT HMDDPSPREM INNFRQVQKF DERLVYTSFS QGIILSLALA 300
GILGICIVVV VSIWLFRRKS IKKGDNKGVI YKPATKMETE AHA 343 |
Gene Ontology | GO:0016021; C:integral to membrane; TAS:ProtInc. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0004089; F:carbonate dehydratase activity; TAS:ProtInc. GO:0008270; F:zinc ion binding; TAS:ProtInc. GO:0015701; P:bicarbonate transport; TAS:Reactome. GO:0006730; P:one-carbon metabolic process; IEA:InterPro. GO:0044281; P:small molecule metabolic process; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |