CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016257
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Low-density lipoprotein receptor-related protein 11 
Protein Synonyms/Alias
 LRP-11 
Gene Name
 LRP11 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
108PDAIIRTKDSLAAGAubiquitination[1]
213KDAPPLSKAGQDVVLubiquitination[1, 2]
381GGDSLVEKSQKATAPubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
 DOMAIN 99 184 MANSC.
 DOMAIN 210 305 PKD.
 DOMAIN 309 345 LDL-receptor class A.
 CARBOHYD 164 164 N-linked (GlcNAc...) (Potential).
 CARBOHYD 291 291 N-linked (GlcNAc...) (Potential).
 CARBOHYD 401 401 N-linked (GlcNAc...) (Potential).
 DISULFID 310 322 By similarity.
 DISULFID 317 335 By similarity.
 DISULFID 329 344 By similarity.  
Keyword
 Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 500 AA 
Protein Sequence
MASVAQESAG SQRRLPPRHG ALRGLLLLCL WLPSGRAALP PAAPLSELHA QLSGVEQLLE 60
EFRRQLQQER PQEELELELR AGGGPQEDCP GPGSGGYSAM PDAIIRTKDS LAAGASFLRA 120
PAAVRGWRQC VAACCSEPRC SVAVVELPRR PAPPAAVLGC YLFNCTARGR NVCKFALHSG 180
YSSYSLSRAP DGAALATARA SPRQEKDAPP LSKAGQDVVL HLPTDGVVLD GRESTDDHAI 240
VQYEWALLQG DPSVDMKVPQ SGTLKLSHLQ EGTYTFQLTV TDTAGQRSSD NVSVTVLRAA 300
YSTGGCLHTC SRYHFFCDDG CCIDITLACD GVQQCPDGSD EDFCQNLGLD RKMVTHTAAS 360
PALPRTTGPS EDAGGDSLVE KSQKATAPNK PPALSNTEKR NHSAFWGPES QIIPVMPDSS 420
SSGKNRKEES YIFESKGDGG GGEHPAPETG AVLPLALGLA ITALLLLMVA CRLRLVKQKL 480
KKARPITSEE SDYLINGMYL 500 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR023415; LDLR_class-A_CS.
 IPR002172; LDrepeatLR_classA_rpt.
 IPR013980; MANSC.
 IPR011106; MANSC_N.
 IPR022409; PKD/Chitinase_dom.
 IPR000601; PKD_dom. 
Pfam
 PF00057; Ldl_recept_a
 PF07502; MANEC 
SMART
 SM00192; LDLa
 SM00765; MANEC
 SM00089; PKD 
PROSITE
 PS01209; LDLRA_1
 PS50068; LDLRA_2
 PS50986; MANSC
 PS50093; PKD 
PRINTS