CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023165
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MKL/myocardin-like protein 2 
Protein Synonyms/Alias
 Megakaryoblastic leukemia 2; Myocardin-related transcription factor B; MRTF-B 
Gene Name
 MKL2 
Gene Synonyms/Alias
 KIAA1243; MRTFB 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
349TILPAPFKPLNDKNSacetylation[1]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. 
Sequence Annotation
 REPEAT 40 65 RPEL 1.
 REPEAT 84 109 RPEL 2.
 REPEAT 128 153 RPEL 3.
 DOMAIN 389 423 SAP.
 REGION 563 591 Required for interaction with itself and
 MOD_RES 66 66 Phosphoserine.
 MOD_RES 367 367 Phosphothreonine.
 MOD_RES 370 370 Phosphothreonine.
 MOD_RES 541 541 Phosphoserine.
 MOD_RES 921 921 Phosphoserine.  
Keyword
 Activator; Alternative splicing; Coiled coil; Complete proteome; Developmental protein; Differentiation; Glycoprotein; Myogenesis; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1088 AA 
Protein Sequence
MIDSSKKQQQ GFPEILTAGD FEPLKEKECL EGSNQKSLKE VLQLRLQQRR TREQLVDQGI 60
MPPLKSPAAF HEQIKSLERA RTENFLKHKI RSRPDRSELV RMHILEETFA EPSLQATQMK 120
LKRARLADDL NEKIAQRPGP MELVEKNILP VDSSVKEAII GVGKEDYPHT QGDFSFDEDS 180
SDALSPDQPA SQESQGSAAS PSEPKVSESP SPVTTNTPAQ FASVSPTVPE FLKTPPTADQ 240
PPPRPAAPVL PTNTVSSAKP GPALVKQSHP KNPNDKHRSK KCKDPKPRVK KLKYHQYIPP 300
DQKGEKNEPQ MDSNYARLLQ QQQLFLQLQI LSQQKQHYNY QTILPAPFKP LNDKNSNSGN 360
SALNNATPNT PRQNTSTPVR KPGPLPSSLD DLKVSELKTE LKLRGLPVSG TKPDLIERLK 420
PYQEVNSSGL AAGGIVAVSS SAIVTSNPEV TVALPVTTLH NTVTSSVSTL KAELPPTGTS 480
NATRVENVHS PLPISPSPSE QSSLSTDDTN MADTFTEIMT MMSPSQFLSS SPLRMTNNED 540
SLSPTSSTLS NLELDAAEKD RKLQEKEKQI EELKRKLEQE QKLVEVLKMQ LEVEKRGQQQ 600
RPLEAQPSAP GHSVKSDQKH GSLGSSIKDE ASLPDCSSSR QPIPVASHAV GQPVSTGGQT 660
LVAKKAVVIK QEVPVGQAEQ QSVVSQFYVS SQGQPPPAVV AQPQALLTTQ TAQLLLPVSI 720
QGSSVTSVQL PVGSLKLQTS PQAGMQTQPQ IATAAQIPTA ALASGLAPTV PQTQDTFPQH 780
VLSQPQQVRK VFTNSASSNT VLPYQRHPAP AVQQPFINKA SNSVLQSRNA PLPSLQNGPN 840
TPNKPSSPPP PQQFVVQHSL FGSPVAKTKD PPRYEEAIKQ TRSTQAPLPE ISNAHSQQMD 900
DLFDILIKSG EISLPIKEEP SPISKMRPVT ASITTMPVNT VVSRPPPQVQ MAPPVSLEPM 960
GSLSASLENQ LEAFLDGTLP SANEIPPLQS SSEDREPFSL IEDLQNDLLS HSGMLDHSHS 1020
PMETSETQFA AGTPCLSLDL SDSNLDNMEW LDITMPNSSS GLTPLSTTAP SMFSADFLDP 1080
QDLPLPWD 1088 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IC:UniProtKB.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
 GO:0048514; P:blood vessel morphogenesis; IEA:Compara.
 GO:0048738; P:cardiac muscle tissue development; IEA:Compara.
 GO:0048568; P:embryonic organ development; IEA:Compara.
 GO:0003007; P:heart morphogenesis; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
 GO:0045844; P:positive regulation of striated muscle tissue development; IDA:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0051145; P:smooth muscle cell differentiation; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR004018; RPEL_repeat.
 IPR003034; SAP_dom. 
Pfam
 PF02755; RPEL
 PF02037; SAP 
SMART
 SM00707; RPEL
 SM00513; SAP 
PROSITE
 PS51073; RPEL
 PS50800; SAP 
PRINTS