UniProt Accession

 STMN2_RAT; P21818; Q9ERH2 

Genbank Protein ID

 AF306458; BC087660 

Genbank Nucleotide ID

 AAG33230.1; AAH87660.1 

Protein Name

 Stathmin-2 

Protein Synonyms/Alias

 Superior cervical ganglion-10 protein; Protein SCG10 

Gene Name

 Stmn2 

Gene Synonyms/Alias

 Scg10; Scgn10 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
129	EENNNFSKMAEEKLI	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone. 

Sequence Annotation

 DOMAIN 38 179 SLD.
 REGION 1 26 Membrane attachment (Potential).
 REGION 39 96 Regulatory/phosphorylation domain
 MOD_RES 16 16 Phosphoserine (Potential).
 MOD_RES 50 50 Phosphoserine (Potential).
 MOD_RES 62 62 Phosphoserine; by MAPK8.
 MOD_RES 73 73 Phosphoserine; by MAPK8.
 MOD_RES 80 80 Phosphoserine (Potential).
 MOD_RES 97 97 Phosphoserine (Potential).
 LIPID 22 22 S-palmitoyl cysteine (By similarity).
 LIPID 24 24 S-palmitoyl cysteine (By similarity).  

Keyword

 Cell projection; Coiled coil; Complete proteome; Cytoplasm; Endosome; Golgi apparatus; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 179 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IEA:UniProtKB-SubCell.
 GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IDA:RGD.
 GO:0030426; C:growth cone; IDA:RGD.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0031982; C:vesicle; IDA:RGD.
 GO:0007026; P:negative regulation of microtubule depolymerization; IEA:Compara.
 GO:0031115; P:negative regulation of microtubule polymerization; IEA:Compara.
 GO:0010977; P:negative regulation of neuron projection development; IEA:Compara.
 GO:0031117; P:positive regulation of microtubule depolymerization; IEA:Compara.
 GO:0010976; P:positive regulation of neuron projection development; IEA:Compara. 

Interpro

 IPR026729; Stathmin-2.
 IPR000956; Stathmin_fam. 

Pfam

 PF00836; Stathmin 

SMART

  

PROSITE

 PS00563; STATHMIN_1
 PS01041; STATHMIN_2
 PS51663; STATHMIN_3 

PRINTS

 PR00345; STATHMIN.