CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037469
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transcription factor 4 
Protein Synonyms/Alias
  
Gene Name
 TCF4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
691RDINEAFKELGRMVQubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 773 AA 
Protein Sequence
MFSKRLEKIA QVPLLFPFIF IILTNYSKME GAVESQPSFF KTSQDIVTCT WVENCYSSFS 60
RRPLEQMFCK HQSKNIISWT GMVAHTCNPS TLGGQGLCDF AKMHHQQRMA ALGTDKELSD 120
LLDFSAMFSP PVSSGKNGPT SLASGHFTGS NVEDRSSSGS WGNGGHPSPS RNYGDGTPYD 180
HMTSRDLGSH DNLSPPFVNS RIQSKTERGS YSSYGRESNL QGCHQQSLLG GDMDMGNPGT 240
LSPTKPGSQY YQYSSNNPRR RPLHSSAMEV QTKKVRKVPP GLPSSVYAPS ASTADYNRDS 300
PGYPSSKPAT STFPSSFFMQ DGHHSSDPWS SSSGMNQPGY AGMLGNSSHI PQSSSYCSLH 360
PHERLSYPSH SSADINSSLP PMSTFHRSGT NHYSTSSCTP PANGTDSIMA NRGSGAAGSS 420
QTGDALGKAL ASIYSPDHTN NSFSSNPSTP VGSPPSLSAG TAVWSRNGGQ ASSSPNYEGP 480
LHSLQSRIED RLERLDDAIH VLRNHAVGPS TAMPGGHGDM HGIIGPSHNG AMGGLGSGYG 540
TGLLSANRHS LMVGTHREDG VALRGSHSLL PNQVPVPQLP VQSATSPDLN PPQDPYRGMP 600
PGLQGQSVSS GSSEIKSDDE GDENLQDTKS SEDKKLDDDK KDIKSITRSR SSNNDDEDLT 660
PEQKAEREKE RRMANNARER LRVRDINEAF KELGRMVQLH LKSDKPQTKL LILHQAVAVI 720
LSLEQQVRER NLNPKAACLK RREEEKVSSE PPPLSLAGPH PGMGDASNHM GQM 773 
Gene Ontology
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0070888; F:E-box binding; IEA:Compara.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Compara.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0001011; F:sequence-specific DNA binding RNA polymerase recruiting transcription factor activity; IEA:Compara.
 GO:0001087; F:TFIIB-class binding transcription factor activity; IEA:Compara.
 GO:0003714; F:transcription corepressor activity; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045666; P:positive regulation of neuron differentiation; IEA:Compara.
 GO:0065004; P:protein-DNA complex assembly; IEA:Compara.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:Compara. 
Interpro
 IPR011598; bHLH_dom. 
Pfam
 PF00010; HLH 
SMART
 SM00353; HLH 
PROSITE
 PS50888; BHLH 
PRINTS