UniProt Accession

 LRP_ECOLI; P0ACJ0; P19494 

Genbank Protein ID

 M35869; D11105; U00096; AP009048 

Genbank Nucleotide ID

 AAA24089.1; BAA01880.1; AAC73975.1; BAA35614.1 

Protein Name

 Leucine-responsive regulatory protein 

Protein Synonyms/Alias

  

Gene Name

 lrp 

Gene Synonyms/Alias

 alsB; ihb; livR; oppI; b0889; JW0872 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
10	DSKKRPGKDLDRIDR	acetylation	[1, 2]
25	NILNELQKDGRISNV	acetylation	[2]
36	ISNVELSKRVGLSPT	acetylation	[2]
129	PDMSAYRKLLGETLL	acetylation	[2]
154	YVVMEEVKQSNRLVI	acetylation	[2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes. 

Sequence Annotation

 DOMAIN 12 73 HTH asnC-type.
 DNA_BIND 31 50 H-T-H motif (Potential).  

Keyword

 3D-structure; Activator; Complete proteome; Direct protein sequencing; DNA-binding; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 164 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0043565; F:sequence-specific DNA binding; IDA:EcoliWiki.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0009098; P:leucine biosynthetic process; IMP:EcoCyc.
 GO:0006355; P:regulation of transcription, DNA-dependent; IMP:EcoliWiki.
 GO:0043201; P:response to leucine; IMP:EcoliWiki.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000485; AsnC-type_HTH_dom.
 IPR011008; Dimeric_a/b-barrel.
 IPR019888; Tscrpt_reg_AsnC-typ.
 IPR019887; Tscrpt_reg_AsnC-typ_C.
 IPR019885; Tscrpt_reg_HTH_AsnC-type_CS.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF01037; AsnC_trans_reg 

SMART

 SM00344; HTH_ASNC 

PROSITE

 PS00519; HTH_ASNC_1
 PS50956; HTH_ASNC_2 

PRINTS

 PR00033; HTHASNC.