UniProt Accession

 S10AE_HUMAN; Q9HCY8; Q5RHT0 

Genbank Protein ID

 AY007220; AF426828; BX470102; BC005019 

Genbank Nucleotide ID

 AAG01893.1; AAM19206.1; CAI14759.1; AAH05019.1 

Protein Name

 Protein S100-A14 

Protein Synonyms/Alias

 S100 calcium-binding protein A14; S114 

Gene Name

 S100A14 

Gene Synonyms/Alias

 S100A15 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
27	RAIETLIKNFHQYSV	ubiquitination	[1, 2]
38	QYSVEGGKETLTPSE	ubiquitination	[1, 2]
93	ELIGEAAKSVKLERP	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. 

Sequence Annotation

 DOMAIN 27 61 EF-hand.  

Keyword

 3D-structure; Apoptosis; Complete proteome; Cytoplasm; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 104 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IDA:HPA.
 GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005509; F:calcium ion binding; NAS:UniProtKB.
 GO:0042379; F:chemokine receptor binding; IMP:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0055074; P:calcium ion homeostasis; NAS:UniProtKB.
 GO:0042742; P:defense response to bacterium; IEP:UniProtKB.
 GO:0071624; P:positive regulation of granulocyte chemotaxis; IDA:UniProtKB.
 GO:0090026; P:positive regulation of monocyte chemotaxis; IDA:UniProtKB.
 GO:0032496; P:response to lipopolysaccharide; IEP:UniProtKB.
 GO:0034142; P:toll-like receptor 4 signaling pathway; IDA:UniProtKB. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR013787; S100_Ca-bd_sub. 

Pfam

 PF01023; S_100 

SMART

  

PROSITE

 PS50222; EF_HAND_2
 PS00303; S100_CABP 

PRINTS