UniProt Accession

 GPX1_RAT; P04041; O08946; Q4PIY2; Q91WZ5 

Genbank Protein ID

 M21210; X07365; X12367; S50336; S41066; AB004231 

Genbank Nucleotide ID

 AAB95647.2; CAB43593.1; CAA30928.2; AAA12407.2; AAK72702.1; BAA20399.2 

Protein Name

 Glutathione peroxidase 1 

Protein Synonyms/Alias

 GPx-1; GSHPx-1; Cellular glutathione peroxidase 

Gene Name

 Gpx1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
62	TEMNDLQKRLGPRGL	acetylation	[1]
86	FGHQENGKNEEILNS	acetylation	[1]
95	EEILNSLKYVRPGGG	acetylation	[1]
112	PNFTLFEKCEVNGEK	acetylation	[1]
119	KCEVNGEKAHPLFTF	acetylation	[1]
146	TALMTDPKYIIWSPV	acetylation	[1]
196	DIEALLSKQPSNP**	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Protects the hemoglobin in erythrocytes from oxidative breakdown. 

Sequence Annotation

 ACT_SITE 47 47
 MOD_RES 146 146 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Oxidoreductase; Peroxidase; Reference proteome; Selenocysteine. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 201 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0043295; F:glutathione binding; IDA:RGD.
 GO:0004602; F:glutathione peroxidase activity; IDA:RGD.
 GO:0047066; F:phospholipid-hydroperoxide glutathione peroxidase activity; IMP:RGD.
 GO:0008430; F:selenium binding; IMP:RGD.
 GO:0007568; P:aging; IEP:RGD.
 GO:0006749; P:glutathione metabolic process; IDA:RGD.
 GO:0042744; P:hydrogen peroxide catabolic process; IDA:RGD.
 GO:0032355; P:response to estradiol stimulus; IEP:RGD.
 GO:0051593; P:response to folic acid; IEP:RGD.
 GO:0009749; P:response to glucose stimulus; IEP:RGD.
 GO:0006982; P:response to lipid hydroperoxide; IMP:RGD.
 GO:0035094; P:response to nicotine; IEP:RGD.
 GO:0010269; P:response to selenium ion; IEP:RGD. 

Interpro

 IPR000889; Glutathione_peroxidase.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00255; GSHPx 

SMART

  

PROSITE

 PS00460; GLUTATHIONE_PEROXID_1
 PS00763; GLUTATHIONE_PEROXID_2
 PS51355; GLUTATHIONE_PEROXID_3 

PRINTS

 PR01011; GLUTPROXDASE.