UniProt Accession

 GSP1_YEAST; P32835; D6VYT9 

Genbank Protein ID

 X71945; L08690; U17243; AY558363; BK006945 

Genbank Nucleotide ID

 CAA50747.1; AAA34653.1; AAB67339.1; AAS56689.1; DAA09605.1 

Protein Name

 GTP-binding nuclear protein GSP1/CNR1 

Protein Synonyms/Alias

 Chromosome stability protein 17; GTPase Ran homolog; Genetic suppressor of PRP20-1 

Gene Name

 GSP1 

Gene Synonyms/Alias

 CNR1; CST17; YLR293C; L8003.19 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
39	HLTGEFEKKYIATIG	acetylation	[1]
73	WDTAGQEKFGGLRDG	acetylation	[1]
101	VTSRITYKNVPNWHR	acetylation	[1]
101	VTSRITYKNVPNWHR	ubiquitination	[2]
125	PIVLCGNKVDVKERK	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Essential for cell viability. By analogy with Ras, Ran may be activated when GTP is exchanged for bound GDP by RCC1 and inactivated when GTP is hydrolyzed by Ran upon activation by RanGAP1. 

Sequence Annotation

 NP_BIND 19 26 GTP (By similarity).
 NP_BIND 67 71 GTP (By similarity).
 NP_BIND 124 127 GTP (By similarity).
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 2 2 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; GTP-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 219 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; TAS:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IGI:SGD.
 GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0006913; P:nucleocytoplasmic transport; TAS:SGD.
 GO:0006997; P:nucleus organization; IGI:SGD.
 GO:0031938; P:regulation of chromatin silencing at telomere; IMP:SGD.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR002041; Ran_GTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase. 

Pfam

 PF00071; Ras 

SMART

 SM00176; RAN 

PROSITE

 PS51418; RAN 

PRINTS

 PR00627; GTPRANTC4.