UniProt Accession

 CYTA_RAT; P01039 

Genbank Protein ID

  

Genbank Nucleotide ID

  

Protein Name

 Cystatin-A 

Protein Synonyms/Alias

 Cystatin-alpha; Epidermal stefin; Epidermal thiol proteinase inhibitor; Cystatin-A, N-terminally processed 

Gene Name

 Csta 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
16	VGGVSEAKPATPEIQ	acetylation	[1]
28	EIQEVADKVKRQLEE	acetylation	[1]
43	KTNEKYEKFKVVEYK	acetylation	[1]
45	NEKYEKFKVVEYKSQ	acetylation	[1]
50	KFKVVEYKSQVVAGQ	acetylation	[1]
74	NGRFLHMKVLRGLSG	acetylation	[1]
86	LSGDDDLKLLDYQTN	acetylation	[1]
96	DYQTNKTKNDELTDF	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 This is an intracellular thiol proteinase inhibitor. 

Sequence Annotation

 MOTIF 52 56 Secondary area of contact.
 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Protease inhibitor; Reference proteome; Thiol protease inhibitor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 103 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
 GO:0010951; P:negative regulation of endopeptidase activity; IEA:GOC. 

Interpro

 IPR000010; Prot_inh_cystat.
 IPR018073; Prot_inh_cystat_CS.
 IPR001713; Prot_inh_stefinA. 

Pfam

 PF00031; Cystatin 

SMART

 SM00043; CY 

PROSITE

 PS00287; CYSTATIN 

PRINTS

 PR00295; STEFINA.