| Tag | Content |
|---|
| CPLM ID | CPLM-019671 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ATP-dependent zinc metalloprotease YME1L1 |
Protein Synonyms/Alias | ATP-dependent metalloprotease FtsH1; Meg-4; Presenilin-associated metalloprotease; PAMP; YME1-like protein 1 |
Gene Name | YME1L1 |
Gene Synonyms/Alias | FTSH1; YME1L; UNQ1868/PRO4304 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 180 | NIAPSFVKGFLLRDR | ubiquitination | [1] | | 201 | LDKLMKTKNIPEAHQ | ubiquitination | [1] | | 221 | GFAEGFLKAQALTQK | ubiquitination | [1] | | 499 | LVNQAALKAAVDGKE | ubiquitination | [1] | | 651 | MTYSDTGKLSPETQS | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1. |
Sequence Annotation | NP_BIND 379 386 ATP (Potential).
ACT_SITE 600 600 By similarity.
METAL 599 599 Zinc; catalytic (By similarity).
METAL 603 603 Zinc; catalytic (By similarity).
METAL 677 677 Zinc; catalytic (By similarity). |
Keyword | Alternative splicing; ATP-binding; Complete proteome; Hydrolase; Membrane; Metal-binding; Metalloprotease; Mitochondrion; Mitochondrion inner membrane; Nucleotide-binding; Protease; Reference proteome; Transmembrane; Transmembrane helix; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 773 AA |
Protein Sequence | MFSLSSTVQP QVTVPLSHLI NAFHTPKNTS VSLSGVSVSQ NQHRDVVPEH EAPSSEPSLN 60
LRDLGLSELK IGQIDQLVEN LLPGFCKGKN ISSHWHTSHV SAQSFFENKY GNLDIFSTLR 120
SSCLYRHHSR ALQSICSDLQ YWPVFIQSRG FKTLKSRTRR LQSTSERLAE TQNIAPSFVK 180
GFLLRDRGSD VESLDKLMKT KNIPEAHQDA FKTGFAEGFL KAQALTQKTN DSLRRTRLIL 240
FVLLLFGIYG LLKNPFLSVR FRTTTGLDSA VDPVQMKNVT FEHVKGVEEA KQELQEVVEF 300
LKNPQKFTIL GGKLPKGILL VGPPGTGKTL LARAVAGEAD VPFYYASGSE FDEMFVGVGA 360
SRIRNLFREA KANAPCVIFI DELDSVGGKR IESPMHPYSR QTINQLLAEM DGFKPNEGVI 420
IIGATNFPEA LDNALIRPGR FDMQVTVPRP DVKGRTEILK WYLNKIKFDQ SVDPEIIARG 480
TVGFSGAELE NLVNQAALKA AVDGKEMVTM KELEFSKDKI LMGPERRSVE IDNKNKTITA 540
YHESGHAIIA YYTKDAMPIN KATIMPRGPT LGHVSLLPEN DRWNETRAQL LAQMDVSMGG 600
RVAEELIFGT DHITTGASSD FDNATKIAKR MVTKFGMSEK LGVMTYSDTG KLSPETQSAI 660
EQEIRILLRD SYERAKHILK THAKEHKNLA EALLTYETLD AKEIQIVLEG KKLEVR 716 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004222; F:metalloendopeptidase activity; IEA:InterPro. GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. GO:0008283; P:cell proliferation; IMP:UniProtKB. GO:0006515; P:misfolded or incompletely synthesized protein catabolic process; IMP:UniProtKB. GO:0007005; P:mitochondrion organization; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |